Conformational flexibility determines the Nf2/merlin tumor suppressor functions
Matrix Biology Plus, 2021 The Neurofibromatosis type 2 gene encodes the Nf2/merlin tumor suppressor protein that is responsible for the regulation of cell proliferation. Once activated, Nf2/merlin modulates adhesive signaling pathways and thereby inhibits cell growth.
Marina C. Primi +3 more
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Merlin tumor suppressor function is regulated by PIP2-mediated dimerization
PLoS ONE, 2023 Neurofibromatosis Type 2 is an inherited disease characterized by Schwann cell tumors of cranial and peripheral nerves. The NF2 gene encodes Merlin, a member of the ERM family consisting of an N-terminal FERM domain, a central α-helical region, and a C ...
Robert F. Hennigan +4 more
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Quinacrine Has Preferential Anticancer Effects on Mesothelioma Cells With Inactivating NF2 Mutations
Frontiers in Pharmacology, 2021 Mesothelioma is a rare cancer with disproportionately higher death rates for shipping and mining populations. These patients have few treatment options, which can be partially attributed to limited chemotherapy responses for tumors.
Derek B. Oien +5 more
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Neurofibromatosis type 2 tumor suppressor protein is expressed in oligodendrocytes and regulates cell proliferation and process formation. [PDF]
PLoS ONE, 2018 The neurofibromatosis type 2 (NF2) tumor suppressor protein Merlin functions as a negative regulator of cell growth and actin dynamics in different cell types amongst which Schwann cells have been extensively studied.
Andrea Toledo +4 more
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Merlin deficiency alters the redox management program in breast cancer
Molecular Oncology, 2021 The expression of Merlin tumor suppressor protein encoded by Neurofibromin 2 (NF2) gene is remarkably decreased in metastatic breast cancer tissues.
Mateus Mota +6 more
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Merlin Falco columbarius preys and feeds offshore
Rivista Italiana di Ornitologia - Research in Ornithology, 2023 This short report describes two cases of predation carried out by Merlin Falco columbarius in open sea, highlighting the ability of this species to feed during active migration.
Fulvio Fraticelli +5 more
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NF2/Merlin suppresses proliferation and induces apoptosis in colorectal cancer cells
Frontiers in Bioscience-Landmark, 2020 Merlin ((Moesin-ezrin-radixin-like protein, also known as schwannomin) is a tumor suppressor protein which is encoded by the neurofibromatosis type 2 gene, NF2.
Xingli Wu +6 more
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Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF complex.
PLoS ONE, 2021 The PAF complex (PAFC) coordinates transcription elongation and mRNA processing and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions both at the cell cortex and nucleus and is a key mediator of ...
Anne E Roehrig +17 more
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Potential Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects
Frontiers in Oncology, 2021 Vestibular schwannomas (VSs, also known as acoustic neuromas) are relatively rare benign brain tumors stem from the Schwann cells of the eighth cranial nerve.
Yu Zhang +5 more
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Neoplasia: An International Journal for Oncology Research, 2011 Mutations in the Neurofibromatosis 2 gene (NF2) predispose to tumors of the nervous system, mainly schwannomas and meningiomas. The NF2 gene encodes for the tumor suppressor protein merlin (moesin-ezrin-radixin-like protein), which functions as a linker ...
Minja Laulajainen +4 more
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