Results 11 to 20 of about 207,836 (317)

Lipid kinase PIP5Kα contributes to Hippo pathway activation via interaction with Merlin and by mediating plasma membrane targeting of LATS1

open access: yesCell Communication and Signaling, 2023
Background The Hippo pathway plays a critical role in controlled cell proliferation. The tumor suppressor Merlin and large tumor suppressor kinase 1 (LATS1) mediate activation of Hippo pathway, consequently inhibiting the primary effectors, Yes ...
Truc Phan Hoang Le   +4 more
doaj   +2 more sources

Merlin regulates signaling events at the nexus of development and cancer

open access: yesCell Communication and Signaling, 2020
Background In this review, we describe how the cytoskeletal protein Merlin, encoded by the Neurofibromin 2 (NF2) gene, orchestrates developmental signaling to ensure normal ontogeny, and we discuss how Merlin deficiency leads to aberrant activation of ...
Mateus Mota, Lalita A. Shevde
doaj   +2 more sources

The Epithelial Circumferential Actin Belt Regulates YAP/TAZ through Nucleocytoplasmic Shuttling of Merlin

open access: yesCell Reports, 2017
Circumferential actin belts underlying the adherens junctions of columnar epithelial cell monolayers control intercellular surface tension and cell shape to maintain tissue integrity.
Kana T. Furukawa   +3 more
doaj   +2 more sources

MiR-25-3p Serves as an Oncogenic MicroRNA by Downregulating the Expression of Merlin in Osteosarcoma

open access: yesCancer Management and Research, 2020
Hua-chun Rao,1,* Zhao-ke Wu,1,* Si-da Wei,1 Yun Jiang,1 Qing-xin Guo,1 Jia-wen Wang,1 Chang-xian Chen,1 Hui-yong Yang2 1Quanzhou Orthopedic-Traumatological Hospital, Fengze District, Quanzhou, Fujian, People’s Republic of China; 2School of Medicine,
Rao H   +7 more
doaj   +2 more sources

Merlin HugeCTR: GPU-accelerated Recommender System Training and Inference [PDF]

open access: yesACM Conference on Recommender Systems, 2022
In this talk, we introduce Merlin HugeCTR. Merlin HugeCTR is an open source, GPU-accelerated integration framework for click-through rate estimation. It optimizes both training and inference, whilst enabling model training at scale with model-parallel ...
Zehuan Wang   +11 more
semanticscholar   +1 more source

As If by Magic: Self-Supervised Training of Deep Despeckling Networks With MERLIN [PDF]

open access: yesIEEE Transactions on Geoscience and Remote Sensing, 2021
Speckle fluctuations seriously limit the interpretability of synthetic aperture radar (SAR) images. Speckle reduction has thus been the subject of numerous works spanning at least four decades.
Emanuele Dalsasso, L. Denis, F. Tupin
semanticscholar   +1 more source

MERLIN - Malware Evasion with Reinforcement LearnINg [PDF]

open access: yesarXiv.org, 2022
In addition to signature-based and heuristics-based detection techniques, machine learning (ML) is widely used to generalize to new, never-before-seen malicious software (malware).
Tony Quertier   +3 more
semanticscholar   +1 more source

THE MERLIN PROJECT: MALAYSIAN STUDENTS’ ACCEPTANCE OF AN AI CHATBOT IN THEIR LEARNING PROCESS

open access: yesThe Turkish Online Journal of Distance Education, 2022
The COVID-19 pandemic has accelerated the educational landscape of institutions of higher education, which were predominantly face-to-face. In Malaysia, many universities converted their courses into online courses to keep up with the challenges of ...
M. Neo
semanticscholar   +1 more source

merlin, an improved framework for the reconstruction of high-quality genome-scale metabolic models

open access: yesNucleic Acids Research, 2022
Genome-scale metabolic models have been recognised as useful tools for better understanding living organisms’ metabolism. merlin (https://www.merlin-sysbio.org/) is an open-source and user-friendly resource that hastens the models’ reconstruction process,
João Capela   +10 more
semanticscholar   +1 more source

Enhancing Students’ Online Learning Experiences with Artificial Intelligence (AI): The MERLIN Project

open access: yesInternational Journal of Technology, 2022
The COVID-19 pandemic led to all institutions of education having to transition to fully online learning almost immediately. However, research showed that online learning still lacked adequate interactions with students.
M. Neo   +6 more
semanticscholar   +1 more source

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