Results 121 to 130 of about 444,796 (301)

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source

Novel guanosine derivatives against MERS CoV polymerase: An in silico perspective

Journal of Biomolecular Structure and Dynamics, 2020
The Middle East Respiratory Syndrome Coronavirus (MERS CoV), also termed camel flu, is a new viral infection that first reported in the year 2012 in the Middle East region and further spread during the last seven years.
Abdo A. Elfiky, Eman B. Azzam
semanticscholar   +1 more source

A Rapid and Specific Assay for the Detection of MERS-CoV [PDF]

Frontiers in Microbiology, 2018
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel human coronavirus that can cause human respiratory disease. The development of a detection method for this virus that can lead to rapid and accurate diagnosis would be significant.
Pei Huang, Pei Huang, Hualei Wang, Hualei Wang, Hualei Wang, Zengguo Cao, Zengguo Cao, Hongli Jin, Hongli Jin, Hang Chi, Jincun Zhao, Jincun Zhao, Beibei Yu, Feihu Yan, Xingxing Hu, Xingxing Hu, Fangfang Wu, Cuicui Jiao, Pengfei Hou, Pengfei Hou, Shengnan Xu, Shengnan Xu, Yongkun Zhao, Yongkun Zhao, Na Feng, Na Feng, Jianzhong Wang, Weiyang Sun, Weiyang Sun, Tiecheng Wang, Tiecheng Wang, Yuwei Gao, Yuwei Gao, Songtao Yang, Songtao Yang, Xianzhu Xia, Xianzhu Xia   +36 more
openaire   +4 more sources

Domestic Pig Unlikely Reservoir for MERS-CoV [PDF]

Emerging Infectious Diseases, 2017
We tested the suitability of the domestic pig as a model for Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Inoculation did not cause disease, but a low level of virus replication, shedding, and seroconversion were observed. Pigs do not recapitulate human MERS-CoV and are unlikely to constitute a reservoir in nature.
Kyle Rosenke, Dana P. Scott, Atsushi Okumura, Elaine Haddock, Heinz Feldmann, Greg Saturday, Rebecca Rosenke, Emmie de Wit, Trenton Bushmaker, Eva Horne, Cynthia Martellaro, Friederike Feldmann   +11 more
openaire   +4 more sources

Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology

Annals of the New York Academy of Sciences, EarlyView.
Bats are recognized to have distinct immune systems from other vertebrates that may allow them to host virulent pathogens without showing disease. However, these flying mammals are also incredibly diverse, such that bats should not be expected to be immunologically homogenous.
Daniel J. Becker, Amanda Vicente‐Santos, Ashley B. Reers, B. R. Ansil, Mika O'Shea, Caroline A. Cummings, Alicia J. Roistacher, Rita M. Quintela‐Tizon, Manuela M. T. Pereira, Juniper Rosen, Arinjay Banerjee, Hannah K. Frank   +11 more
wiley   +1 more source

A systematic review of emerging respiratory viruses at the Hajj and possible coinfection with Streptococcus pneumoniae [PDF]

, 2018
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Benkouiten, Samir, Memish, Ziad A.   +2 more
core   +1 more source

Advance in the assembly of the plant mitochondrial genomes using high‐throughput DNA sequencing data of total cellular DNAs

Plant Biotechnology Journal, EarlyView.
Summary The assembly of plant mitochondrial genomes presents unique challenges due to difficulties in isolating mitochondrial DNA (mtDNA) and plant mitochondrial genome characteristics, such as low interspecific conservation; sequence sharing among mitochondrial, nuclear and plastid DNAs; and complex structural variations.
Yang Ni, Jingling Li, Yihui Tan, Guoan Shen, Chang Liu   +4 more
wiley   +1 more source

Animal Welfare as an Essential Element of One Health

Animal Research and One Health, EarlyView.
Philip Lymbery
wiley   +1 more source

Structural Design and Immunogenicity of a Novel Self‐Adjuvanting Mucosal Vaccine Candidate for SARS‐CoV‐2 Expressed in Plants

Plant Biotechnology Journal, EarlyView.
ABSTRACT Mucosal vaccination for COVID‐19 to boost preexisting though insufficient systemic and local/mucosal immunity remains an attractive prospect but there are currently no licensed mucosal vaccines against this infection. Here, using a plant expression system, we developed a novel mucosal vaccine platform for respiratory viruses and demonstrated ...
Mi‐Young Kim, Andy Cano Tran, Ju Kim, Humblenoble Stembridge Ayuk, Adam Sparrow, Lorenzo Bossi, Megan Brown, Emil Joseph Vergara, Kathrin Göritzer, Elisabetta Groppelli, Tae‐Ho Kwon, Julian K. C. Ma, Yong‐Suk Jang, Rajko Reljic   +13 more
wiley   +1 more source

Knowledge and attitudes towards Middle East respiratory sydrome-coronavirus (MERS-CoV) among health care workers in south-western Saudi Arabia.

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 2020
Background Saudi Arabia is considered the epicentre of MERS-CoV. Since 2012, a total of 1844 cases of MERS-CoV have been reported. A recent cluster, with 8 cases, has been reported in Najran region in the south-western region of the country.
A. Asaad, R. El-Sokkary, Mahdi Alzamanan, M. El-Shafei   +3 more
semanticscholar   +1 more source