Results 61 to 70 of about 75,632 (172)

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source

Domestic Pig Unlikely Reservoir for MERS-CoV [PDF]

Emerging Infectious Diseases, 2017
We tested the suitability of the domestic pig as a model for Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Inoculation did not cause disease, but a low level of virus replication, shedding, and seroconversion were observed. Pigs do not recapitulate human MERS-CoV and are unlikely to constitute a reservoir in nature.
Kyle Rosenke, Dana P. Scott, Atsushi Okumura, Elaine Haddock, Heinz Feldmann, Greg Saturday, Rebecca Rosenke, Emmie de Wit, Trenton Bushmaker, Eva Horne, Cynthia Martellaro, Friederike Feldmann   +11 more
openaire   +4 more sources

A chimeric MERS-CoV virus-like particle vaccine protects mice against MERS-CoV challenge

Virology Journal, 2022
Abstract Background Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease in humans, with a case fatality rate of approximately 35%, thus posing a considerable threat to public health.
Jung-Eun Park, Ji-Hee Kim, Jae-Yeon Park, Sung-Hoon Jun, Hyun-Jin Shin   +4 more
openaire   +3 more sources

Host Species Restriction of Middle East Respiratory Syndrome Coronavirus through Its Receptor, Dipeptidyl Peptidase 4 [PDF]

, 2014
Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012. Recently, the MERS-CoV receptor dipeptidyl peptidase 4 (DPP4) was identified and the specific interaction of the receptor-binding domain (RBD) of MERS-CoV spike protein and DPP4 was
Bushmaker, Trenton, Kinne, Joerg, McLellan, Jason S., Miazgowicz, Kerri L., Milne-Price, Shauna, Munster, Vincent J., Robertson, Shelly, Scott, Dana, van Doremalen, Neeltje, Zhu, Jiang   +9 more
core   +3 more sources

Caring for Patients With Infectious Diseases: Nurses' Risk Perception, Moral Distress, Professional Ethos and Emotional Labor: A Mixed Methods Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aims To examine the relationship between hospital nurses' self‐perceived risk when caring for patients with infectious diseases and their moral distress, and how this relationship affects their emotional labour, while examining the moderating role of professional ethos.
Naimi Etti, Bluvstein Irit, Itzhaki Michal   +2 more
wiley   +1 more source

Point‐of‐Care Testing by Multiplex‐PCR in Different Compartments in Suspected Lower Respiratory Tract Infection After Lung Transplantation—Results of a Prospective Study

Transplant Infectious Disease, EarlyView.
Use of POCtmPCR with noninvasive samples (NPS and sputum) in LTx recipients with viral LRTI are a viable alternative to invasive BAL sampling, ABSTRACT Background Respiratory tract infections (RTIs) are a leading cause of morbidity and mortality following lung transplantation (LTx).
Susanne Simon, Merle Sophie Kaiser, Marcus Bachmann, Gérard Krause, Jens Gottlieb   +4 more
wiley   +1 more source

Cyclophilin inhibitors restrict Middle East respiratory syndrome coronavirus via interferon-λ in vitro and in mice [PDF]

, 2020
While severe coronavirus infections, including Middle East respiratory syndrome coronavirus (MERS-CoV), cause lung injury with high mortality rates, protective treatment strategies are not approved for clinical use.
Dietzel, Erik, Fink, Ludger, Gattenloehner, Stefan, Gruber, Achim D., Hofmann, Nina, Hoppe, Judith, Kupke, Alexandra, Meier, Lars, Sauerhering, Lucie, Witte, Biruta   +9 more
core   +1 more source

Genomes of two Extinct‐in‐the‐Wild reptiles from Christmas Island reveal distinct evolutionary histories and conservation insights

Molecular Ecology Resources, Volume 25, Issue 5, July 2025.
Abstract Genomics can play important roles in biodiversity conservation, especially for Extinct‐in‐the‐Wild species where genetic factors greatly influence risk of total extinction and probability of successful reintroductions. The Christmas Island blue‐tailed skink (Cryptoblepharus egeriae) and Lister's gecko (Lepidodactylus listeri) are two endemic ...
Tristram O. Dodge, Katherine A. Farquharson, Claire Ford, Lisa Cavanagh, Kristen Schubert, Molly Schumer, Katherine Belov, Carolyn J. Hogg   +7 more
wiley   +1 more source

Effective inhibition of MERS-CoV infection by resveratrol [PDF]

BMC Infectious Diseases, 2017
Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that causes severe morbidity and mortality. Up to date, there is no approved or licensed vaccine or antiviral medicines can be used to treat MERS-CoV-infected patients.
Wen-Ho Chuo, Tony T. Wang, Shiming Li, Shih-Chao Lin, Chi-Tang Ho, Chi-Chen Lin   +5 more
openaire   +3 more sources

COVID‐19‐Associated Cytotoxic Lesions of the Corpus Callosum in Chinese Patients: A Retrospective Study

Brain and Behavior, Volume 15, Issue 6, June 2025.
We report the clinical characteristics, radiological features, and changes in inflammatory markers throughout the entire course of illness in eight patients with COVID‐19‐associated CLOCCs. The neurological symptoms or signs in these patients included altered consciousness, headache, cognitive impairment, ataxia, dysarthria, pyramidal signs, and visual
Chenyi Wan, Menghua Li, Yanyan Yu, Si Luo, Daojun Hong, Meihong Zhou, Yu Zhu   +6 more
wiley   +1 more source