Results 61 to 70 of about 59,724 (178)

Immunization of MERS-CoV-2-infected mice with a sublethal dose of MERS-CoV or VRP-MERS-S

STAR Protocols, 2023
Here, we detail the immunization of mice with a sublethal dose of MERS-CoV or two doses of replication-incompetent alphavirus replicon particles expressing MERS-CoV spike protein. We then describe steps to determine the outcome of immunization by challenging immunized mice with a lethal dose of MERS-CoV, as well as by detecting virus-specific ...
Jian Zheng, Rudra Channappanavar, Stanley Perlman   +2 more
openaire   +3 more sources

Newcastle disease virus-based MERS-CoV candidate vaccine elicits high-level and lasting neutralizing antibodies in Bactrian camels

Journal of Integrative Agriculture, 2017
: Middle East respiratory syndrome coronavirus (MERS-CoV), a member of the Coronaviridae family, is the causative pathogen for MERS that is characterized by high fever, pneumonia, acute respiratory distress syndrome (ARDS), as well as extrapulmonary ...
Ren-qiang LIU, Jin-ying GE, Jin-ling WANG, Yu SHAO, Hui-lei ZHANG, Jin-liang WANG, Zhi-yuan WEN, Zhi-gao BU   +7 more
doaj   +1 more source

The Role of Polyphenols in Respiratory and Gut Health: From the Perspective of Gut‐Lung Axis

Phytotherapy Research, Volume 40, Issue 8, Page 5071-5089, August 2026.
ABSTRACT The gut‐lung axis constitutes a dynamic, multidirectional communication platform between the gastrointestinal and respiratory tracts. Its complexity arises from the integrated crosstalk among the microbiota, immune system, and redox homeostasis, collectively influencing disease susceptibility and progression.
Jian Kang, YongJun Du, Yanmei Hou, Liangliang Hao, Zhen Chen, Haoyang Xie, Chuantao Zhang, Lei Li   +7 more
wiley   +1 more source

A dual-targeting approach using a human bispecific antibody against the receptor-binding domain of the Middle East Respiratory Syndrome Coronavirus

Virus Research
The emergence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has posed a significant global health concern due to its severe respiratory illness and high fatality rate.
Ji Hyun Lee, Ji Woong Kim, Hee Eon Lee, Jin Young Song, Ah Hyun Cho, Jae Hyeon Hwang, Kyun Heo, Sukmook Lee   +7 more
doaj   +1 more source

Quantifying Heterogeneous Impacts of Geolocated mHealth Tracing on Spatiotemporal Transmission of Emerging Infections

GeoHealth, Volume 10, Issue 8, August 2026.
Abstract Digital health tools, including mobile device location‐based health (mHealth) applications, have been adopted to augment conventional contact tracing during recent epidemics and pandemics, yet quantitative evidence about their added epidemiological value remains limited. Using aggregated, privacy‐preserving mHealth data from six Chinese cities
Zhifeng Cheng, Hao Liang, Fei Gao, Xuyao Chen, Xiao Liu, Yuping Zhou, Xu Chen, Hui Jiang, Samantha Cockings, Andrew Tatem, Shengjie Lai, Chu He   +11 more
wiley   +1 more source

Assessing the Origin of the COVID19 Pandemic Is Still Important

FASEB BioAdvances, Volume 8, Issue 8, August 2026.
ABSTRACT The COVID19 pandemic, caused by the betacoronavirus SARS‐CoV‐2, now ranks among the world's deadliest plagues, and certainly one of the most significant public health crises in the last 100 years. Despite more than 6 years of investigating the pandemic, it has been difficult to assess the origin of the disease in the City of Wuhan, China.
Jason D. Bannan
wiley   +1 more source

The prevalence of Middle East respiratory Syndrome coronavirus (MERS-CoV) infection in livestock and temporal relation to locations and seasons

Journal of Infection and Public Health, 2018
Background: The Middle East respiratory syndrome (MERS) has been reported for the first time infecting a human being since 2012. The WHO was notified of 27 countries have reported cases of MERS, the majority of these cases occur in the Arabian Peninsula,
Samy Kasem, Ibrahim Qasim, Ali Al-Doweriej, Osman Hashim, Ali Alkarar, Ali Abu-Obeida, Mohamed Saleh, Ali Al-Hofufi, Hussein Al-Ghadier, Raed Hussien, Ali AL-Sahaf, Faisal Bayoumi, Asmaa Magouz   +12 more
doaj   +1 more source

Machine Learning of Personal Repertoires From Public T Cell Receptors

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT The T‐cell receptor (TCR) repertoire records an individual's immunological history, but most unique CDR3 sequences in any one person are private and uninformative about anyone else. A small subset, however, recurs predictably across unrelated donors.
Or Malca, Alona Zilberberg, Sol Efroni
wiley   +1 more source

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh, Rumpa Banerjee, Hailah M. Almohaimeed, Amany I. Almars, Tahani Ahmad ALMatrafi, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Kranti Kiran Reddy Ealla, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Spread, Circulation, and Evolution of the Middle East Respiratory Syndrome Coronavirus

mBio, 2014
The Middle East respiratory syndrome coronavirus (MERS-CoV) was first documented in the Kingdom of Saudi Arabia (KSA) in 2012 and, to date, has been identified in 180 cases with 43% mortality.
Matthew Cotten, Simon J. Watson, Alimuddin I. Zumla, Hatem Q. Makhdoom, Anne L. Palser, Swee Hoe Ong, Abdullah A. Al Rabeeah, Rafat F. Alhakeem, Abdullah Assiri, Jaffar A. Al-Tawfiq, Ali Albarrak, Mazin Barry, Atef Shibl, Fahad A. Alrabiah, Sami Hajjar, Hanan H. Balkhy, Hesham Flemban, Andrew Rambaut, Paul Kellam, Ziad A. Memish   +19 more
doaj   +1 more source