Results 61 to 70 of about 27,602 (177)

MERS-CoV: Ein aktueller Überblick [PDF]

Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie, 2013
The following article gives a current overview of the newly emerging Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Since first time in summer 2012 in some countries in the Arabian Peninsula there were a number of severe infections of the respiratory tract caused by the new coronavirus.
Bundschuh, Matthias, Klingelhoefer, Doris   +1 more
openaire   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]

, 2016
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Memish, Ziad A.
core   +1 more source

RBD‐SD1 Nanoparticle Vaccines From DPP4‐Using Merbecoviruses Elicit a Cross‐Reactive Antibody Response but Limited Cross‐Protective Immunity

Biotechnology and Bioengineering, EarlyView.
SpyCatcher‐mi3 nanoparticles displaying RBD‐SD1 from MERS‐CoV, NL140422, and HKU4 elicited robust and cross‐reactive IgG responses in mice. Only MERS‐CoV RBD‐SD1 induced neutralizing antibodies against MERS‐CoV and protected human DPP4 mice from a MERS‐CoV challenge, indicating conserved serologic but limited cross‐neutralizing epitopes.
Peter J. Halfmann, Jeong Soo Lee, Tong Wang, Augustine Duffy, Janie E. Rogers, Natasha Chen, Elizabeth Frimpong, Carmen Rai, Yoshihiro Kawaoka, Ravi S. Kane   +9 more
wiley   +1 more source

Middle East respiratory syndrome coronavirus specific antibodies in naturally exposed Israeli llamas, alpacas and camels

One Health, 2018
Thus far, no human MERS-CoV infections have been reported from Israel. Evidence for the circulation of MERS-CoV in dromedaries has been reported from almost all the countries of the Middle East, except Israel.
Dan David, Ditza Rotenberg, Evgeny Khinich, Oran Erster, Svetlana Bardenstein, Michael van Straten, Nisreen M.A. Okba, Stalin V. Raj, Bart L. Haagmans, Marcelo Miculitzki, Irit Davidson   +10 more
doaj   +1 more source

The sample of choice for detecting Middle East respiratory syndrome coronavirus in asymptomatic dromedary camels using real-time reverse-transcription polymerase chain reaction [PDF]

, 2016
The newly identified Middle East respiratory syndrome coronavirus (MERS-CoV), which causes severe respiratory disease, particularly in people with comorbidities, requires further investigation.
Al Dhahiry, S.H.S. (Said), Al Romaihi, H.E. (Hamad), Al-Marri, S.A. (Salih), Al-Mawlawi, N. (Naema), Al-Thani, M. (Mohamed), Alhajri, F. (Farhoud), AlHajri, M.M. (Mohd), El-Maghraby, M.M. (Mamdouh M.), El-Sayed, A.M. (Ahmed M.), Farag, E. (Elmoubasher), Ghobashy, H. (Hazem), Haagmans, B.L. (Bart), Koopmans D.V.M., M.P.G. (Marion), Lamers, M.M. (Mart M.), Mohran, K.A. (Khaled A.), Pas, S.D. (Suzan), Raj, V.S. (Stalin), Reusken, C.B.E.M. (Chantal), Smits, S.L. (Saskia), Voermans, J. (Jolanda)   +19 more
core   +1 more source

MERS-CoV: Bridging the Knowledge Gaps

Oman Medical Journal, 2014
Since its emergence in September 2012 and as of 30 April 2014, there have been 424 cases of the Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) reported to public health authorities worldwide (15 countries). This tally includes 95 healthcare workers (22%) and 131 deaths (mortality rate of 31%).1 To date, only two laboratory confirmed cases have
Abdullah Balkhair, Fatma Ba Alawi, Khuloud Al Maamari, Zakaria Al Muharrmi, Osama Ahmed   +4 more
openaire   +3 more sources

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

A novel luciferase immunosorbent assay performs better than a commercial enzyme-linked immunosorbent assay to detect MERS-CoV specific IgG in humans and animals

Biosafety and Health, 2019
The Middle East respiratory syndrome (MERS) is a lethal zoonosis caused by MERS coronavirus (MERS-CoV) and poses a significant threat to public health worldwide.
Wenling Wang, Tianyu Wang, Yao Deng, Peihua Niu, Ruhan A, Jincun Zhao, Malik Peiris, Shixing Tang, Wenjie Tan   +8 more
doaj   +1 more source

Estimating potential incidence of MERS-CoV associated with Hajj pilgrims to Saudi Arabia, 2014 [PDF]

, 2014
Between March and June 2014 the Kingdom of Saudi Arabia (KSA) had a large outbreak of MERS-CoV, renewing fears of a major outbreak during the Hajj this October.
Albarrak, Ali, Cummings, Derek A T, Ferguson, Neil M, Garske, Tini, Hakeem, Rafat, Lessler, Justin, Mills, Harriet, Rodriguez-Barraquer, Isabel, The MERS-CoV Scenario Modeling Working Group,, Truelove, Shaun, Van Kerkhove, Maria   +10 more
core   +1 more source