Results 61 to 70 of about 252,954 (227)
Advanced Science, EarlyView.This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding +13 more
wiley +1 more source
The Phylogeography of MERS-CoV in Hospital Outbreak-Associated Cases Compared to Sporadic Cases in Saudi Arabia [PDF]
, 2020 This study compared the phylogeography of MERS-CoV between hospital outbreak-associated cases and sporadic cases in Saudi Arabia. We collected complete genome sequences from human samples in Saudi Arabia and data on the multiple risk factors of human ...
Chen, Xin +11 more
core +1 more source
Evaluating MERS-CoV Entry Pathways [PDF]
, 2019 Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic pathogen with a broad host range. The extent of MERS-CoV in nature can be traced to its adaptable cell entry steps. The virus can bind host-cell carbohydrates as well as proteinaceous receptors.
Qing, Enya +3 more
openaire +2 more sources
Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases
Animal Models and Experimental Medicine, EarlyView.Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam +4 more
wiley +1 more source
−1 PRF Structural similarity for SARS-CoV, SARS-CoV-2, and MERS-CoV as predicted by RNAz.
, 2023 Gaps in the alignment are represented as hyphen. Asterisks (*) in bottom row (PK location) correspond to the known location of SARS-CoV-2 and MERS-CoV −1 PRF native structures.
Ulrike Stege (12338189) +4 more
core +1 more source
One Health, 2018 Thus far, no human MERS-CoV infections have been reported from Israel. Evidence for the circulation of MERS-CoV in dromedaries has been reported from almost all the countries of the Middle East, except Israel.
Dan David +10 more
doaj +1 more source
Immunization of MERS-CoV-2-infected mice with a sublethal dose of MERS-CoV or VRP-MERS-S
STAR Protocols, 2023 Here, we detail the immunization of mice with a sublethal dose of MERS-CoV or two doses of replication-incompetent alphavirus replicon particles expressing MERS-CoV spike protein. We then describe steps to determine the outcome of immunization by challenging immunized mice with a lethal dose of MERS-CoV, as well as by detecting virus-specific ...
Jian Zheng +2 more
openaire +3 more sources
Characterization and immunogenicity of nanoparticle vaccines displaying embecovirus spike proteins
Biotechnology Progress, EarlyView.Virus‐like particle vaccines displaying spike proteins from OC43, HKU1 A, and HKU1 B were evaluated in mice for their ability to elicit antibodies against the spike proteins from OC43, HKU1 A, HKU1 B, and HKU1 C. Abstract Endemic human coronaviruses OC43 and HKU1 cause widespread respiratory infections and can be associated with severe illness in ...
Peter J. Halfmann +6 more
wiley +1 more source
Studying Evolutionary Adaptation of MERS-CoV [PDF]
, 2019 Forced viral adaptation is a powerful technique employed to study the ways viruses may overcome various selective pressures that reduce viral replication. Here, we describe methods for in vitro serial passaging of Middle East respiratory syndrome coronavirus (MERS-CoV) to select for mutations which increase replication on semi-permissive cell lines as ...
Letko, Michael, Munster, Vincent
openaire +2 more sources
A chimeric MERS-CoV virus-like particle vaccine protects mice against MERS-CoV challenge
Virology Journal, 2022 Abstract Background Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease in humans, with a case fatality rate of approximately 35%, thus posing a considerable threat to public health.
Jung-Eun Park +4 more
openaire +3 more sources