Results 71 to 80 of about 85,740 (261)

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Middle East respiratory syndrome coronavirus in the last two years: Health care workers still at risk [PDF]

, 2019
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Memish, Ziad A.
core   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

A novel luciferase immunosorbent assay performs better than a commercial enzyme-linked immunosorbent assay to detect MERS-CoV specific IgG in humans and animals

Biosafety and Health, 2019
The Middle East respiratory syndrome (MERS) is a lethal zoonosis caused by MERS coronavirus (MERS-CoV) and poses a significant threat to public health worldwide.
Wenling Wang, Tianyu Wang, Yao Deng, Peihua Niu, Ruhan A, Jincun Zhao, Malik Peiris, Shixing Tang, Wenjie Tan   +8 more
doaj   +1 more source

MERS-CoV (Middle East Respiratory Syndrome Coronavirus) outside the Arabian Peninsula an One Health approach: Understanding the role of wildlife, livestock and human in the virus dynamic [PDF]

, 2016
One of the big paradoxes of the MERS-CoV epidemiology is the apparent lack of human cases in large parts Africa where the virus and an animal host, the dromedary camel, are present.
Akhmetsadykov, Nourlan, Ayelet, Gelagay, Baubekova, Almagul, Ben Bencheikh, M.N., Bourgarel, Mathieu, Boussini, H., Chevalier, Véronique, Chu, Daniel K.W., El Berbri, Ikhlass, Fassi-Fihri, Ouafaa, Faye, Bernard, Fekadu, G., Grosbois, Vladimir, Maher, W., Miguel, Eve, Peiris, Malik, Perera, Ranawaka A.P.M., Roche, Benjamin, Roger, François, Shimekit, D., Traoré, Amadou, Van Kerkhove, Maria D.   +21 more
core  

MERS-CoV spillover at the camel-human interface [PDF]

, 2018
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus from camels causing significant mortality and morbidity in humans in the Arabian Peninsula.
Abdallah, Adney, Ali, Almutairi, Antia, Assiri, Assiri, Assiri, Assiri, Azhar, Bedford, Blumberg, Boni, Bouckaert, Briese, Bruen, Carpenter, Cauchemez, Chen, Chu, Corman, Cotten, Cotten, De Maio, Drosten, Drosten, Drummond, Drummond, Dudas, Dudas, Dudas, Dudas, Fagbo, Faria, Frost, Gill, Gire, Grubaugh, Guindon, Haagmans, Hasegawa, Heled, Hemida, Herrewegh, Hon, Hunter, Kandeil, Kapoor, Katoh, Keck, Kim, Kim, Kosakovsky Pond, Kottier, Kühnert, Lai, Lamers, Lau, Lemey, Lipsitch, Liu, Lloyd-Smith, Lu, Lycett, Makino, Martinez, Martinez-Bakker, Memish, Mueller, Müller, Müller, Notohara, Park, Park, Park, Plipat, Quick, Raj, Rasmussen, Reed, Reusken, Reusken, Reusken, Sabir, Seong, Smith, Turner, van Boheemen, Vaughan, Volz, Volz, Wernery, Wernery, WHO MERS-Cov Research Group, World Health Organization, World Health Organization, Xie, Yang, Zaki, Zhang   +99 more
core   +2 more sources

MERS-CoV– Low risk to Canadians

Canada Communicable Disease Report, 2014
Middle East respiratory syndrome - Coronavirus (MERS-CoV) -- is a novel coronavirus that has caused a number of community-acquired cases and health care associated outbreaks in Saudi Arabia and the United Arab Emirates (UAE) as well as sporadic cases in other countries, especially in the Middle East.
M, Saboui, F, Reyes-Domingo, E, Levreault, T, Mersereau   +3 more
openaire   +2 more sources

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development

Advanced Science, EarlyView.
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin   +12 more
wiley   +1 more source

Middle East respiratory syndrome coronavirus in dromedary camels: An outbreak investigation [PDF]

, 2014
Background: Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe lower respiratory tract infection in people. Previous studies suggested dromedary camels were a reservoir for this virus.
Al Dhahiry, S.H.S. (Said), Al Khal, A. (Abdullatif), Al Romaihi, H.E. (Hamad), Al-Marri, S.A. (Salih), Al-Thani, M. (Mohamed), Alhajri, F. (Farhoud), AlHajri, M.M. (Mohd), Bermingham, A. (Alison), Diab, A. (Ayman), Farag, E. (Elmoubasher), Galiano, M. (Monica), Ghobashy, H. (Hazem), Godeke, G-J. (Gert-Jan), Haagmans, B.L. (Bart), Jonges, M. (Marcel), Koopmans D.V.M., M.P.G. (Marion), Myers, R.H. (Richard), Osterhaus, A.D.M.E. (Albert), Raj, V.S. (Stalin), Reusken, C.B.E.M. (Chantal)   +19 more
core   +1 more source

A novel coronavirus, MERS-CoV

Uirusu, 2013
A novel human coronavirus was identified in Saudi Arabia and Qatar as the causative agent of severe acute respiratory diseases in 2012. The virus was termed Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and is taken notice of important coronavirus caused severe diseases to human after the outbreak of severe acute respiratory syndrome (SARS ...
openaire   +3 more sources