Results 141 to 150 of about 467,339 (358)

Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors

Nature Structural & Molecular Biology, 2019
The Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and often lethal respiratory illness in humans, and no vaccines or specific treatments are available. Infections are initiated via binding of the MERS-CoV spike (S) glycoprotein to
Young-Jun Park, A. Walls, Zhaoqian Wang, M. Sauer, Wentao Li, M. A. Tortorici, B. Bosch, F. DiMaio, D. Veesler   +8 more
semanticscholar   +1 more source

The Actin‐Binding Prolyl‐Isomerase Par17 Sustains Its Substrate Selectivity by Interdomain Allostery

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The human peptidyl‐prolyl‐cis/trans isomerases (PPIases), Parvulin 14 and Parvulin 17, accelerate the cis/trans isomerization of Xaa‐Pro moieties within protein sequences. By modulating the respective binding interfaces of their target proteins, they play a crucial role in determining the fate of their substrates within the cell. Although both
Anna Sternberg, Jennifer Lynne Borger, Mathilda Thies, Anja Matena, Mike Blueggel, Bianca E. Kamba, Christine Beuck, Farnusch Kaschani, Markus Kaiser, Peter Bayer   +9 more
wiley   +1 more source

Quality of life reported by survivors after hospitalization for Middle East respiratory syndrome (MERS)

Health and Quality of Life Outcomes, 2019
Introduction Data are lacking on impact of Middle East Respiratory Syndrome (MERS) on health-related quality of life (HRQoL) among survivors. Methods We conducted a cross-sectional survey of MERS survivors who required hospitalization in Saudi Arabia ...
Sarah Batawi, Nehal Tarazan, Rajaa Al-Raddadi, Eman Al Qasim, Anees Sindi, Sameera AL Johni, Fahad M. Al-Hameed, Yaseen M. Arabi, Timothy M. Uyeki, Basem M. Alraddadi   +9 more
doaj   +1 more source

Characteristics of flavonoids as potent MERS‐CoV 3C‐like protease inhibitors

Chemical Biology and Drug Design, 2019
Middle East respiratory syndrome‐coronavirus (MERS‐CoV) is a zoonotic virus transmitted between animals and human beings. It causes MERS with high mortality rate. However, no vaccine or specific treatment is currently available.
S. Jo, Hyojin Kim, Suwon Kim, D. Shin, Mi‐Sun Kim   +4 more
semanticscholar   +1 more source

Transforming Niclosamide through Nanotechnology: A Promising Approach for Long COVID Management

Small, EarlyView.
This review highlights the transformation of niclosamide, a repurposed drug, through molecular science strategies to overcome its pharmacokinetic limitations. Emphasizing novel nanohybrid technologies and delivery platforms, the article explores their therapeutic potential in targeting the complex pathophysiology of long COVID, paving the way for ...
Sanoj Rejinold N, Goeun Choi, Geun‐woo Jin, Jin‐Ho Choy   +3 more
wiley   +1 more source

Identification of a Novel Inhibitor against Middle East Respiratory Syndrome Coronavirus

Viruses, 2017
The Middle East respiratory syndrome coronavirus (MERS-CoV) was first isolated in 2012, and circulated worldwide with high mortality. The continual outbreaks of MERS-CoV highlight the importance of developing antiviral therapeutics.
Yaping Sun, Huaidong Zhang, Jian Shi, Zhe Zhang, Rui Gong   +4 more
doaj   +1 more source

Near‐Infrared Fluorescent Single‐Walled Carbon Nanotubes for Biosensing

Small, EarlyView.
Near‐infrared fluorescent single‐walled carbon nanotubes (SWCNTs) stand out as versatile biosensors due to their spectral overlap with the biological transparency window, surface‐sensitive fluorescence emission, and chemical modularity. This review offers a concise guide to understanding the photophysics of SWCNTs, various functionalization strategies,
Srestha Basu, Gili Bisker
wiley   +1 more source

Dimeric DNA Aptamers for the Spike Protein of SARS‐CoV‐2 Derived from a Structured Library with Dual Random Domains

Small Methods, EarlyView.
Dimeric in a single go: A novel DNA aptamer library has been designed to yield dimeric aptamers in a single in vitro selection. Tested against the SARS‐CoV‐2 spike protein, this dual random domain (DRD) library with two 25‐nucleotide random regions and a 20‐nucleotide poly‐thymidine linker produced high‐affinity dimeric aptamers with KD values as low ...
Ryan Amini, Jian Ma, Zijie Zhang, Qing Wang, Jimmy Gu, Leyla Soleymani, Yingfu Li   +6 more
wiley   +1 more source

Critical behavior of long straight rigid rods on two-dimensional lattices: Theory and Monte Carlo simulations

, 2008
The critical behavior of long straight rigid rods of length $k$ ($k$-mers) on square and triangular lattices at intermediate density has been studied. A nematic phase, characterized by a big domain of parallel $k$-mers, was found.
A. J. Ramirez-Pastor, D. A. Matoz-Fernandez, D. H. Linares, Freed K. F.   +3 more
core   +1 more source

Rapid and Sensitive Detection of RNA Viruses through Imaging of Marker Molecules Derived from Designed Circular DNA Probes

Small Methods, EarlyView.
This study presents a rapid and sensitive virus detection method that employs imaging of virus‐specific DNA markers. Utilizing specially designed single‐stranded circular DNA probes, this method captures RNA fragments from RNase‐digested viral genomes during the reverse transcriptase‐based reaction, resulting in double‐stranded markers that are ...
Yoon‐ha Jang, Taesoo Kim, Su‐jin Hong, Se‐yeon Kim, Hyeseung Hwang, Siwon Kim, Su‐a Kang, Nabin Won, Dogeun Kim, Min Jae Kim, Yong Pil Chong, Seongsoo Jang, Kyubong Jo, Kwang‐il Lim   +13 more
wiley   +1 more source