Results 71 to 80 of about 21,837 (337)

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

The CK1 gene family: expression patterning in zebrafish development

Biological Research, 2007
Protein kinase CK1 is a ser/thr protein kinase family which has been identified in the cytosol cell fraction, associated with membranes as well as in the nucleus.
AMELINA ALBORNOZ, JOSÉ M YÁÑEZ, CLAUDIA FOERSTER, CELESTE AGUIRRE, LUISA PEREIRO, VERÓNICA BURZIO, MAURICIO MORAGA, ARIEL E REYES, MARCELO ANTONELLI   +8 more
doaj  

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source

The Effect of Exercise with and without Consumption of Hydroalcoholic Extract of Eriobotrya Japonica Flower on Mesencephalic Astrocyte-derived Neurotrophic Factor in the Cerebellum of Rats Subjected to6-Hydroxydopamine

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2015
Background and Objectives:Previous researchs has shown that exercise and antioxidants consumption have positive effect on oxidative stress. Therefore, this study was carried out aiming at investigating the effects of 12 weeks of exercise on a running ...
Raziyeh Mohammadi, Zia Fallah Mohammadi, Molook Mohammadi, Aboalghasem Taghavi Holagh   +3 more
doaj  

Automatic quantitative MRI texture analysis in small-for-gestational-age fetuses discriminates abnormal neonatal neurobehavior.

PLoS ONE, 2013
BackgroundWe tested the hypothesis whether texture analysis (TA) from MR images could identify patterns associated with an abnormal neurobehavior in small for gestational age (SGA) neonates.MethodsUltrasound and MRI were performed on 91 SGA fetuses at 37
Magdalena Sanz-Cortes, Giuseppe A Ratta, Francesc Figueras, Elisenda Bonet-Carne, Nelly Padilla, Angela Arranz, Nuria Bargallo, Eduard Gratacos   +7 more
doaj   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Brain stem acoustic evoked potentials recorded from the human mesencephalon

, 1991
Near field brain stem evoked potentials (NF-BAEPs) were recorded by means of an intraparenchymatous electrode placed in the right mesencephalon, during a stereotactic-guided biopsy of a tumor.
Landi, A, Colombo, F
core   +1 more source

Combining Spatial Multi‐Omics Data to Decipher Spatial Domains and Elucidate Cell Heterogeneity Based on Self‐Supervised Graph Learning

Advanced Science, EarlyView.
A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu, Rui Qiao, Ying Li, Junhong Li, Nuoya Yue, Jing Ge, Jiao Wang, Luonan Chen, Peiluan Li   +8 more
wiley   +1 more source

Heterogeneous distribution of Kir3 potassium channel proteins within dopaminergic neurons in the mesencephalon of the rat brain [PDF]

, 2001
0 Titelblatt und Inhaltsverzeichnis 1 Einleitung 8 1.1 Ionenkanäle 8 1.2 Kaliumkanäle 8 1.3 Einwärtsgleichrichtende Kaliumkanäle (Kir-Kanäle) 11 1.4 Kir3-Kanäle 14 1.5 Basalganglien und ventrales Mesencephalon 18 ...
Eulitz, Dirk
core   +1 more source

Gene expression mapping of conserved GABAergic interneuron markers in developing zebrafish

Frontiers in Molecular Neuroscience
γ-Aminobutyric acid (GABA)-expressing interneurons play a crucial role in regulating brain activity, and their impairment or loss is linked to various neurological disorders.
Bingyao Zhu, Bingyao Zhu, Scott C. Baraban, Scott C. Baraban, Scott C. Baraban   +4 more
doaj   +1 more source