Results 81 to 90 of about 21,837 (337)

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

open access: yesAdvanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu   +13 more
wiley   +1 more source

Myelin and myelinization in the telencephalon and mesencephalon of the lizard Gallotia galloti as revealed by the immunohistochemical localization of myelin basic protein

open access: yes, 1992
We have studied in the telencephalon and mesencephalon of the lizard Gallotia galloti the localization and the chronology of appearance of the immunoreactivity due to the presence of a myelin-specific protein: the Myelin Basic Protein (MBP).
de Barry, J.   +3 more
core   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan   +29 more
wiley   +1 more source

Driver Behavior Modeling with Subjective Risk‐Driven Inverse Reinforcement Learning

open access: yesAdvanced Intelligent Systems, EarlyView.
A subjective risk‐driven inverse reinforcement learning framework is proposed to model driver decision‐making. It infers drivers' risk perception and risk tolerance from driving data. A learnable risk threshold is used to regulate decisions, enabling interpretable and human‐like driving behavior decisions.
Yang Liang   +6 more
wiley   +1 more source

Early Subset of Cerebellar Nuclei Neurons Derived from Mesencephalon in Mice

open access: yes, 2017
During cerebellar development, cerebellar nuclei (CN) neurons and Purkinje cells are the earliest born among the different neuronal subtypes. Purkinje cells are the sole output of the cerebellar cortex and project to the CN.
Xiaodan Jiao   +4 more
core   +1 more source

Isthmus organizer and regionalization of the mesencephalon and metencephalon

open access: yesThe International Journal of Developmental Biology, 2005
The brain vesicles that are formed at an early stage of neural development are the fundamentals of the brain plan. Heterotopic transplantation revealed that the diencephalon could change its fate when juxtaposed to the isthmus (mes-metencephalic boundary), which indicated that the isthmus functions as an organizer for the mesencephalon and ...
Harukazu, Nakamura, Yuji, Watanabe
openaire   +3 more sources

Research progress on biomarkers of traumatic brain injury

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen   +8 more
wiley   +1 more source

Determining the Sufficiency of the bHLH Gene Nato3 in Dopamine Neurogenesis

open access: yes, 2012
Floor plate cells of the mesencephalon have the ability to become more floor plate cells or differentiate into dopamine containing neurons. Maturation of these neurons can be marked by the stage of differentiation. When dopamine neurons of the substantia
Kaufman, Darcy Nichole
core   +1 more source

Liver growth factor modulated the expression of phospho-Akt and Bcl2 in the striatum and mesencephalon of 6-OHDA-lesioned rats.

open access: yes, 2013
As shown in A, the decrease in phospho-Akt/Akt ratio observed in vehicle-treated rats (A, white bar) was prevented 24 hours after the administration of a single injection of LGF (A, lined bar). In the lesioned mesencephalon, the phospho-Akt/Akt ratio was
Rafael Gonzalo-Gobernado (430684)   +8 more
core   +1 more source

The Analgesia of Lesion of Mesencephalon Tractus Spinothalamicus on One Side and Nucleus Centralis Thalamus on the Other Side in Rats

open access: yes针刺研究, 1999
This study was undertaken to evaluate the analgesic effect of electrical lesion of mesencephalon tractus spinothalamicus and nucleus centralis thalamus with tail stimulation-vocalization test and tailflick latency.
龚素珍, 唐斌, 龙大宏
doaj  

Home - About - Disclaimer - Privacy