A vasoactive role for endogenous relaxin in mesenteric arteries of male mice. [PDF]
PLoS ONE, 2014 The peptide hormone relaxin has striking effects on the vascular system. Specifically, endogenous relaxin treatment reduces myogenic reactivity through nitric oxide (NO)-mediated vasorelaxation and increases arterial compliance in small resistance ...
Chen Huei Leo +4 more
doaj +4 more sources
Dapagliflozin induces vasodilation in resistance-size mesenteric arteries by stimulating smooth muscle cell KV7 ion channels [PDF]
Heliyon, 2022 Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that, in addition to glucose reduction, lowers systemic blood pressure. Here, we investigated if dapagliflozin could directly relax small mesenteric arteries that control peripheral ...
Ahasanul Hasan +3 more
doaj +2 more sources
ET-CORM Mediated Vasorelaxation of Small Mesenteric Arteries: Involvement of Kv7 Potassium Channels [PDF]
Frontiers in Pharmacology, 2021 Although the vasoactive properties of carbon monoxide (CO) have been extensively studied, the mechanism by which CO mediates vasodilation is not completely understood.
Danfeng Zhang +8 more
doaj +2 more sources
Frontiers in Pharmacology, 2017 Background and purpose: We have shown that in vitro treatment with cannabidiol (CBD, 2 h) enhances endothelial function in arteries from Zucker diabetic fatty (ZDF) rats, partly due to a cyclooxygenase (COX)-mediated mechanism.
Amanda J. Wheal +4 more
doaj +2 more sources
Risk-Assessment of Esophageal Surgery: Diagnosis and Treatment of Celiac Trunk Stenosis [PDF]
The Thoracic & Cardiovascular Surgeon Reports, 2018 Anastomotic leakage of the gastric conduit following surgical treatment of esophageal cancer is a life-threatening complication. An important risk factor associated with anastomotic leakage is calcification of the supplying arteries of the gastric ...
Rosa G.M. Lammerts +3 more
doaj +4 more sources
PLoS ONE, 2018 Background and purposeIncreasing evidence suggests that the omega-3 polyunsaturated acids (n-3 PUFA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are beneficial to cardiovascular health, promoting relaxation of vascular smooth muscle ...
Roshan Limbu +2 more
doaj +2 more sources
AdipoRon, adiponectin receptor agonist, improves vascular function in the mesenteric arteries of type 2 diabetic mice. [PDF]
PLoS ONE, 2020 BACKGROUND:An orally active synthetic adiponectin receptor agonist, AdipoRon has been suggested to ameliorate insulin resistance, and glucose tolerance.
Soo-Kyoung Choi +4 more
doaj +2 more sources
Coupling of store-operated calcium entry to vasoconstriction is acid-sensing ion channel 1a dependent in pulmonary but not mesenteric arteries. [PDF]
PLoS ONE, 2020 Although voltage-gated Ca2+ channels (VGCC) are a major Ca2+ entry pathway in vascular smooth muscle cells (VSMCs), several other Ca2+-influx mechanisms exist and play important roles in vasoreactivity.
Selina M Garcia +4 more
doaj +2 more sources
Clinical and Experimental Hypertension, 2023 Objective Endothelial dysfunction is a critical initiating factor in the development of hypertension and related complications. Follistatin-like 1 (FSTL1) can promote endothelial cell function and stimulates revascularization in response to ischemic ...
Hanwen Liu +6 more
doaj +1 more source
Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling [PDF]
, 2015 Type 2 diabetes (DM2) increases the risk of cardiovascular disease. Aldosterone, which has pro-oxidative and pro-inflammatory effects in the cardiovascular system, is positively regulated in DM2.
Bruder-Nascimento, Thiago +7 more
core +11 more sources