Results 61 to 70 of about 574,783 (292)

Fast Spherical Centroidal Voronoi Mesh Generation: A Lloyd-preconditioned LBFGS Method in Parallel

, 2018
Centroidal Voronoi tessellation (CVT)-based mesh generation is a very effective technique for creating high-quality Voronoi meshes and their dual Delaunay triangulations that often play a crucial role in applications, including ocean and atmospheric ...
Gunzburger, Max, Ju, Lili, Yang, Huanhuan   +2 more
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

High-order curvilinear hybrid mesh generation for CFD simulations

, 2018
We describe a semi-structured method for the generation of high-order hybrid meshes suited for the simulation of high Reynolds number flows. This is achieved through the use of highly stretched elements in the viscous boundary layers near the wall ...
Bucklow, Henry, Gammon, Mark, Marcon, Julian, Moxey, David, Peiró, Joaquim, Pollard, Claire R., Turner, Michael   +6 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

An anisotropic mesh adaptation method for the finite element solution of heterogeneous anisotropic diffusion problems

, 2010
Heterogeneous anisotropic diffusion problems arise in the various areas of science and engineering including plasma physics, petroleum engineering, and image processing.
Aavatsmark, Aavatsmark, Ait-Ali-Yahia, Borouchaki, Borouchaki, Brackbill, Brandts, Brandts, Burman, Castro-Díaz, Chan, Chan, Ciarlet, Ciarlet, Crumpton, Dompierre, Draˇgaˇnescu, Dvinsky, Eigestad, Ern, Frey, Gűnter, Gűnter, Gűnter, Habashi, Huang, Huang, Huang, Huang, Huang, Jacquotte, Karras, Karátson, Karátson, Karátson, Knupp, Knupp, Kornhuber, Kuzmin, Křížek, Le Potier, Le Potier, Le Potier, Letniowski, Lipnikov, Liska, Mlacnik, Mumford, Nishikawa, Peraire, Perona, Rachowicz, Rachowicz, Remacle, Sharma, Sommerville, Stix, Stoyan, Stoyan, Strang, Varga, Varga, Weickert, Weizhang Huang, Xianping Li, Xu   +65 more
core   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Neuroinflammation in GAD65 Antibody‐Associated Epilepsy Measured Using [18F]DPA‐714 PET/MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody‐associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA‐714 and PET to evaluate brain microglial activation.
Jingjing Chen, Yuying Zhang, Heyu Zhang, Jinming Zhang, Ningning Wang, Xintong Guo, Yicong Liu, Yue Liu, Xiangsong Zhang, Ziyi Chen, Guanzhong Ni   +10 more
wiley   +1 more source

Template mapping method for plane quadrilateral mesh generation with controllable density transitions

Engineering Reports
In this article, we integrate the template method and the mapping method to propose a new approach for generating quadrilateral meshes with controllable density transitions for planar geometric models.
Yize Li, Qingyuan Hu, Gengdong Cheng
doaj   +1 more source

Layered Polymer Injection Throttle Valve Core Structure Optimization Design

Journal of Harbin University of Science and Technology, 2017
In order to solve the separate layer polymer injection in polymer underground low shear injection allocation problem and improve the oil displacement effect of polymer，this paper compares the three kinds of valve structure，spool indoor test，and a valve ...
YOU Bo, ZOU Tian-yang, JIA De-li
doaj   +1 more source