Results 1 to 10 of about 63,844 (255)

Kinematic Characteristic Analysis of Hypoid Gear based on Two Kinds of Eigenfunction

Jixie chuandong, 2021
Based on the classical space meshing theory， two kinds of basic eigenfunctions and eigenvectors of conjugate surfaces are defined. The function of the two kinds of eigenfunctions in the analysis of the meshing characteristics of conjugate surfaces is ...
Bingyang Wei, Ke Zhang, Bo Zhang, Yuliang Guo   +3 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effect of Leading Edge Protuberance on Thrust Production of a Dynamically Pitching Aerofoil [PDF]

, 2017
The paper presents a computational analysis of the characteristics of a NACA 634-021 aerofoil modified by incorporating sinusoidal leading-edge protuberances at Re = 14,000.
Benaissa, M., Ho, W.H., Ibrahim, I.H., New, T.H.   +3 more
core   +2 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Investigating the Effect of Water Contamination on Gearbox Lubrication based on Motor Control Data from a Sensorless Drive [PDF]

, 2014
Water is one of the most significant destructive contaminations to lubricants which in turn lead to more power consumption and early damage to rotating machines.
Abusaad, Samieh, Ball, Andrew, Benghozzi, Ahmed, Brethee, Khaldoon F., Gu, Fengshou   +4 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Study on the Meshing Characteristic of Parallel Axis Line Gear

Jixie chuandong, 2018
The meshing characteristics of parallel axis line gear including sliding rate,contact ratio,meshing contact model and meshing frequency are studied,comparing to the inherent characteristics of spur gear that covers the node impact,the dynamic ...
Chen Yangzhi, Zhu Anshi, Lü Yueling
doaj  

Study on Meshing Stiffness and Dynamic Characteristics of Fine High Tooth Gears

Jixie chuandong, 2023
In order to study the vibration characteristics of fine high tooth gears, a pair of standard gears and fine high gears are taken as comparative experimental objects, and the translation torsion dynamic model of a spur gear transmission system is ...
Zhang Xiangfeng, Shang Jun, Zhou Jianxing, Fei Xiang   +3 more
doaj  

A method for static and dynamic load analysis of standard and modified spur gears [PDF]

, 1983
The mesh stiffness and dynamic load characteristics for several cases of the Normal Contract Ratio and High Contact ratio gearing. The considered contact ratios were grouped in the general range of 1.7,2.0, and 2.3.
Kasuba, R.
core   +1 more source