The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
MESHING THEORY ANALYSIS OF THE MODIFIED ROLLER ENVELOPING HOURGLASS WORM DRIVE
Based on the modification of the single-roller-enveloped toroidal meshing worm drive, a parabolic modified roller-enveloped toroidal meshing worm drive is obtained.
QI Yan +4 more
doaj
Misalignment diagnosis of a planetary gearbox based on vibration analysis [PDF]
As a critical power transmission system, planetary gearbox is widely used in many industrial important machines such as wind turbines, aircraft turbine engines, helicopters.
Abdalla, Gaballa M. +5 more
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
In order to improve the transmission capability by exploring the relationship between torsional stiffness on output shaft and load meshing characteristics, a simulation model of finite element analysis (FEA) is built to evaluate the performance of tooth ...
Xing Jingzhong +3 more
doaj
Simulation and experimental verification of W-band finite frequency selective surfaces on infinite background with 3D full wave solver NSPWMLFMA [PDF]
We present the design, processing and testing of a W-band finite by infinite and a finite by finite Grounded Frequency Selective Surfaces (FSSs) on infinite background.
Bogaert, Ignace +7 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Dynamic analysis of double-helical gear system considering effect of oil film among meshing teeth
The oil film among meshing teeth is just like a spring-damping element, and it can dominate the friction and meshing characteristics of the gear pair and influence its dynamic performances further.
Minghu Yin +4 more
doaj +1 more source
Image based simulation of one-dimensional compression tests on carbonate sand [PDF]
High factors of safety and conservative methods are commonly used on foundation design on shelly carbonate soils. A better understanding of the behavior of this material is, thus, critical for more sustainable approaches for the design of a number of ...
A Munjiza +12 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source

