Results 41 to 50 of about 63,518 (304)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Spatial Tooth Profile Design of Triple-circular-arc Harmonic Gears and Finite Element Simulation of Torsional Stiffness

Jixie chuandong, 2023
In order to improve the transmission capability by exploring the relationship between torsional stiffness on output shaft and load meshing characteristics, a simulation model of finite element analysis (FEA) is built to evaluate the performance of tooth ...
Xing Jingzhong, Chen Liang, Chen Xiaoxia, Yao Yunpeng   +3 more
doaj  

Leakage flow simulation in a specific pump model [PDF]

, 2014
This paper deals with the influence of leakage flow existing in SHF pump model on the analysis of internal flow behaviour inside the vane diffuser of the pump model performance using both experiments and calculations. PIV measurements have been performed
BAYEUL-LAINE, Annie-Claude, BOIS, Gérard, DAZIN, Antoine, DUPONT, Patrick, ROUSSETTE, Olivier, SI, Qiaorui   +5 more
core   +6 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dynamic analysis of double-helical gear system considering effect of oil film among meshing teeth

Advances in Mechanical Engineering, 2020
The oil film among meshing teeth is just like a spring-damping element, and it can dominate the friction and meshing characteristics of the gear pair and influence its dynamic performances further.
Minghu Yin, Yahui Cui, Xiangjun Meng, Jinzhong Zuo, Yuhao Qi   +4 more
doaj   +1 more source

Exploring the Interplay between CAD and FreeFem++ as an Energy Decision-Making Tool for Architectural Design [PDF]

, 2018
The energy modelling software tools commonly used for architectural purposes do not allow a straightforward real-time implementation within the architectural design programs.
Fernández Nieto, Enrique Domingo, Galán-Marín, Carmen, Rivera-Gómez, Carlos, Rojas Fernández, Juan Manuel   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Kinematic Characteristic Analysis of Hypoid Gear based on Two Kinds of Eigenfunction

Jixie chuandong, 2021
Based on the classical space meshing theory， two kinds of basic eigenfunctions and eigenvectors of conjugate surfaces are defined. The function of the two kinds of eigenfunctions in the analysis of the meshing characteristics of conjugate surfaces is ...
Bingyang Wei, Ke Zhang, Bo Zhang, Yuliang Guo   +3 more
doaj  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source