Results 41 to 50 of about 65,517 (305)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Diagnosis of Combination Faults in a Planetary Gearbox using a Modulation Signal Bispectrum based Sideband Estimator [PDF]

, 2015
This paper presents a novel method for diagnosing combination faults in planetary gearboxes. Vibration signals measured on the gearbox housing exhibit complicated characteristics because of multiple modulations of concurrent excitation sources, signal ...
Abdallaa, Gaballa M., Ball, Andrew D., Gu, Fengshou, Rehab, Ibrahim, Tian, Xiange, Wang, Tie   +5 more
core   +1 more source

Development of a multiblock procedure for automated generation of two-dimensional quadrilateral meshes of gear drives [PDF]

, 2020
This article describes a new multiblock procedure for automated generation of two-dimensional quadrilateral meshes of gear drives. The typical steps of the multiblock schemes have been investigated in depth to obtain a fast and simple way to mesh ...
Roda-Casanova, Victor, Sanchez-Marin, Francisco   +1 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Design and optimization of fuel injection of a 50 kW micro turbogas [PDF]

, 2018
The present article deals with the design of a micro turbogas turbine suitable for on board applications, e.g., as a power generator on hybrid transit bus, characterized by a simple constructive approach.
Achille, Manuele, Capata, Roberto
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Investigating the Effect of Water Contamination on Gearbox Lubrication based on Motor Control Data from a Sensorless Drive [PDF]

, 2014
Water is one of the most significant destructive contaminations to lubricants which in turn lead to more power consumption and early damage to rotating machines.
Abusaad, Samieh, Ball, Andrew, Benghozzi, Ahmed, Brethee, Khaldoon F., Gu, Fengshou   +4 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

The low-noise optimisation method for gearbox in consideration of operating conditions [PDF]

, 2014
This paper presents a comprehensive procedure to calculate the steady dynamic response and the noise radiation generated from a stepping-down gearbox.
Kang, J, Sun, W, Tao, Q, Zhou, J
core   +1 more source

Fast approximate dimensioning and performance analysis of mesh optical networks [PDF]

Fourth International Workshop on Design of Reliable Communication Networks, 2003. (DRCN 2003). Proceedings., 2004
This paper presents a collection of approximation formulas that allow a network planner to quickly estimate the size of a mesh optical network with limited inputs. In particular, it provides a set of equations that relate number of sites, average fiber connectivity, demand load and capacity for various mesh protection architectures.
J.-F. Labourdette, E. Bouillet, R. Ramamurthy, A.A. Akyamac   +3 more
openaire   +1 more source