Results 111 to 120 of about 100,425 (314)

Pediatric patient with peritoneal mesothelioma harboring ALK rearrangement

Current Problems in Cancer: Case Reports, 2021
Malignant mesothelioma is a rare disease that typically occurs in older patients with prolonged exposure to asbestos. The majority of mesothelioma occurs in the pleura.
Reema A Patel, MD, Miranda Lin, BS, Megan M Harper, MS, MD, Sandra J Beck, MD, Charles S Dietrich, MD, Jill M Kolesar, PhD, MS, Susanne M Arnold, MD, John Hahn, MD, Prakash K Pandalai, MD, Shadi A Qasem, MD, Joseph Kim, MD   +10 more
doaj  

Transplantation of the MSLN‐deficient Thymus Generates MSLN Epitope Reactive T Cells to Attenuate Tumor Progression

Cancer Science, Volume 116, Issue 4, Page 871-883, April 2025.
In the present study, mesothelin (MSLN) deficiency in thymus induced the development of MSLN reactive T cells that had anti‐tumor functions against MSLN‐expressing tumor cells. In AOM‐DSS induced mouse colorectal cancer model, transplantation of MSLN‐deficient thymus repressed the colorectal cancer progression with elevated number of IFNγ‐expressing T ...
Hanchao Gao, Haiyan Wu, Lvwen Ning, Liying Zhou, Mengtao Cao, Wenting Huang, Xihong Xie, Haidong Wu, Xiehui Chen, Feiqiang Chen, Jinqi Song, Kai Deng, Pengfei Chen   +12 more
wiley   +1 more source

MONITORING OF MESOTHELIOMA IN SOUTHERN BRAZIL: A SITUATION TO BE INVESTIGATED

Cogitare Enfermagem, 2017
Brazil is one of the world’s greatest producers of chrysotile, but the occurrence of mesothelioma is apparently low. However, identification of cases of mesothelioma is difficult due to errors of diagnosis and registries of deaths.
Francisco José Koller, Leila Maria Mansano Sarquis, Maria de Fátima Mantovani, Fernanda Moura D’Almeida Miranda, Dario Consonni, Carolina Mensi   +5 more
doaj   +1 more source

A Mutual Interaction Between GSTP1 and p53 Improves the Drug Resistance and Malignant Biology of Pancreatic Cancer

Cancer Science, Volume 116, Issue 5, Page 1268-1281, May 2025.
The specific role of Glutathione S‐transferase P1 (GSTP1) in pancreatic cancer (PC) has rarely been investigated. In current study, our results suggest that the positive feedback regulation of GSTP1 and wildtype p53 (wtp53) plays a significant role in cell proliferation, drug resistance, cell invasion and metastasis in PC.
Guosen Wang, Yi Cao, Tengcheng Hu, Zhengqing Cai, ChuanPing Chen, Qilong Geng, Xinyu Luo, Yang Liu, Weijie Wang, Jiabin Jin, Weiwei Sheng   +10 more
wiley   +1 more source

Peritoneal mesothelioma

British Journal of Hospital Medicine, 2010
A 59-year-old building surveyor presented with a 2-month history of lethargy and abdominal swelling. There was no associated abdominal pain, change in bowel habit or jaundice. There was no significant past medical history. His alcohol intake was approximately 60 units per week.
James, Berrill, Hasan, Haboubi, Paul, Duane   +2 more
openaire   +4 more sources

VCP Promotes Cholangiocarcinoma Development by Mediating BAP1 Ubiquitination‐Dependent Degradation

Cancer Science, EarlyView.
It demonstrates the tumor‐suppressive roles of BAP1 in CCA: BAP1 significantly inhibits CCA cell proliferation and tumor progression. It identifies VCP as a key upstream regulator mediating BAP1 homeostasis: VCP binds to BAP1 and promotes the latter's ubiquitination degradation via the ubiquitin‐proteasome pathway.
Peiying Zhang, Xiangning Liu, Yue Liu, Hongdao Zhu, Churun Zheng, Qi Ling, Fangjie Yan, Qiaojun He, Hong Zhu, Tao Yuan, Bo Yang   +10 more
wiley   +1 more source

Pleuropericardial mesotheliomas: A report of two unusual cases

Asian Journal of Oncology, 2018
Mesothelioma is an aggressive malignant tumor of the mesothelium. The majority of mesotheliomas arise from the pleura. However, less commonly mesothelioma can arise in other locations such as peritoneal, pericardium, or tunica vaginalis testis. We report
Harsha Vardhana Kuruba Ramanjaneyulu, Anu Kapoor, Chinmayee Biswal, Phani Chakravrty Mutnuru   +3 more
doaj   +1 more source

Novel TEAD1 Inhibitor VT103 Enhances Dabrafenib Efficacy in BRAF V600E Mutated Lung Adenocarcinoma via Survivin Downregulation

Cancer Science, EarlyView.
We established a novel patient‐derived BRAF V600E‐mutated lung adenocarcinoma cell line and demonstrated that combining a novel TEAD1 inhibitor (VT103) with dabrafenib enhances therapeutic efficacy through survivin downregulation. Our tissue microarray analysis revealed a strong correlation between YAP1, TEAD1, and survivin expression in lung ...
Kazutaka Hosoya, Hiroaki Ozasa, Hironori Yoshida, Hitomi Ajimizu, Takahiro Tsuji, Masatoshi Yamazoe, Tatsuya Ogimoto, Kentaro Hashimoto, Tomoko Funazo (Yamamoto), Keiichiro Suminaga, Yusuke Shima, Hiroshi Yoshida, Takashi Nomizo, Hiroaki Ito, Kazuhiro Terada, Shigeto Nishikawa, Toshi Menju, Akihiko Yoshizawa, Hiroshi Date, Toyohiro Hirai   +19 more
wiley   +1 more source

Relations between approved platinum drugs and non-coding RNAs in mesothelioma

Non-coding RNA Research, 2018
Malignant mesothelioma diseases feature an increasing risk due to their severe forms and their association with asbestos exposure. Platinum(II) complexes such as cisplatin and carboplatin are clinically approved for the therapy of mesothelioma often in ...
Bernhard Biersack
doaj  

KEYNOTE‐A17: First‐Line Pembrolizumab Plus Cisplatin–Pemetrexed in Japanese Participants With Advanced Pleural Mesothelioma

Cancer Science, EarlyView.
In the phase 1b KEYNOTE‐A17 study of first‐line pembrolizumab plus chemotherapy in Japanese participants with advanced pleural mesothelioma (PM), 2 of 18 participants (11%) evaluated experienced dose‐limiting toxicities. The objective response rate among all 19 participants in the study was 74%, with 14 participants achieving a partial response and a ...
Takashi Kijima, Terufumi Kato, Yasushi Goto, Kozo Kuribayashi, Koji Mikami, Yoshiki Negi, Shuji Murakami, Tatsuya Yoshida, Masae Homma, Akira Wakana, Kazuo Noguchi, Nobukazu Fujimoto   +11 more
wiley   +1 more source