Results 71 to 80 of about 110,409 (295)

Anti-PD1 does not improve pyroptosis induced by γδ T cells but promotes tumor regression in a pleural mesothelioma mouse model

Frontiers in Immunology, 2023
IntroductionMesothelioma is an aggressive tumor in the pleural cavity that is difficult to treat. Diagnosis is usually late with minimal treatment options available for the patients and with unfavorable outcomes. However, recent advances in immunotherapy
Ka Sin Lui, Zuodong Ye, Hoi Ching Chan, Yoshimasa Tanaka, Allen Ka Loon Cheung   +4 more
doaj   +1 more source

Cytopathologic Features of Metastatic Malignant Mesothelioma With SMARCB1 (INI‐1) Deficient Diagnosed by Ultrasound‐Guided Fine‐Needle Aspiration: A Case Report

Diagnostic Cytopathology, EarlyView.
ABSTRACT Malignant mesothelioma (MM) is a rare yet aggressive neoplasm that arises from mesothelial cells lining the thoracic and abdominal cavities, the pericardium, and the tunica testis. Characterized by rapid progression, high invasiveness, and a poor prognosis, MM poses significant clinical challenges. SMARCB1, also referred to as INI‐1, hSNF5, or
Jun Yang, Juandi Liu, Jing Jin, Deng Pan, Lei Shao   +4 more
wiley   +1 more source

Durable complete response in a patient with BRAF-mutated advanced melanoma with ocular and skin toxicities from BRAF/MEK targeted therapy after immune checkpoint inhibitor treatment: a case report

Dermatology Reports
Here we report the case of a woman suffering from advanced melanoma who developed severe toxicities with BRAF and MEK inhibitors (BRAFis, MEKis), given as second-line therapy after failure of immunotherapy, who achieved a complete and durable response ...
Carlotta Bertolina, Marinella Bertolotti, Claudia Leporati, Antonina Maria De Angelis, Sara Delfanti, Luigi Cerbone, Marco Ghiglione, Federica Grosso   +7 more
doaj   +1 more source

Concomitant Nephrotic Syndrome and Cryoglobulinemia in a Case of Malignant Mesothelioma

Case Reports in Nephrology, 2022
Malignant pleural mesothelioma is rarely associated with nephrotic syndrome. Cryoglobulinemia is found in various pathological statuses, such as hepatitis C virus infection but rarely in malignant neoplasms.
Kei Nagai, Hiroaki Tachi, Kohei Inoue, Atsushi Ueda   +3 more
doaj   +1 more source

Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report

JTO Clinical and Research Reports, 2021
Malignant mesothelioma with EWSR1-ATF1 fusion is a rare malignancy described in young adults without asbestos exposure. To the best of our knowledge, outcomes to local and systemic therapies for this subtype of malignant mesothelioma have not been ...
Helen Ke, MBBS (Hons), Anthony J. Gill, AM, MBBS, FRCPA, Catriona McKenzie, MBBS (Hons1), FRCPA, James G. Kench, MBBS, Bsc(Med), FRCPA, Renee C.F. Chan, MBBS(Hons1), FRCPA, Nick Pavlakis, BSc, MBBS, MMed(Clin. Epi), PhD, FRACP, Michael Fulham, MBBS(Hons), FRACP, Cherry Koh, MBBS (Hons), MS, FRACS, Steven Kao, BHB, MBChB, PhD, FRACP   +8 more
doaj   +1 more source

Tsc1-Tp53 loss induces mesothelioma in mice, and evidence for this mechanism in human mesothelioma [PDF]

, 2015
Mesothelioma is diagnosed in approximately 2,500 patients in the United States every year, most often arising in the pleural space, but also occurring as primary peritoneal mesothelioma.
Bueno, Raphael, Chirieac, Lucian R., Guo, Yanan, Kwiatkowski, David J., Malinowska, Izabela A., Pass, Harvey, Wu, Wenhao   +6 more
core   +1 more source

Peritoneal mesothelioma [PDF]

Postgraduate Medical Journal, 1990
Summary We report two patients who presented with small bowel obstruction secondary to peritoneal mesothelioma. The difficulties in establishing this diagnosis at an early stage are illustrated. Recent advances in the management of peritoneal mesothelioma are reviewed.
J H, Anderson, C J, Stewart, D T, Hansell, J R, Anderson   +3 more
openaire   +2 more sources

Treatment and survival of patients with esophageal and gastric cancer in the Netherlands and Belgium: A population‐based comparison

International Journal of Cancer, EarlyView.
What's New? Marked differences in esophageal and gastric cancer survival rates exist between the Netherlands and Belgium, for reasons that remain unclear. In this study, the authors in‐vestigated these differences and attempted to identify contributing factors.
Benthe H. Doeve, Steven C. Kuijper, Geert Silversmit, Lien van Walle, Philippe Nafteux, Camiel Rosman, Pauline A. J. Vissers, Paul Jeene, Laurens V. Beerepoot, Sarah Derks, Amine Karimi, Maarten F. Bijlsma, Hanneke W. M. van Laarhoven, Rob H. A. Verhoeven   +13 more
wiley   +1 more source

Constitutive inflammation and epithelial-mesenchymal transition dictate sensitivity to nivolumab in CONFIRM: a placebo-controlled, randomised phase III trial

Nature Communications
Leveraging adaptive tumour immunity to control mesothelioma via immune checkpoint blockade is now a standard therapeutic approach. However, the determinants of sensitivity remain elusive.
Dean A. Fennell, Kayleigh Hill, Min Zhang, Charlotte Poile, Sean Ewings, Essa Y. Baitei, Joanna Dzialo, Nada Nusrat, Jan Rogel, Daniel Faulkner, Christian Ottensmeier, Raffaele Califano, Gerard G. Hanna, Sarah Danson, Nicola Steele, Mavis Nye, Lucy Johnson, Kim Mallard, Joanne Lord, Calley Middleton, Peter Szlosarek, Sam Chan, Liz Darlison, Peter Wells-Jordan, Cathy Richards, James Harber, Aleksandra Bzura, Jake Spicer, Catrin Pritchard, Tamihiro Kamata, Jens C. Hahne, Maymun Jama, Edward J. Hollox, Jason F. Lester, Jin-Li Luo, Zisen Zhou, Hongji Yang, Huiyu Zhou, Astero Klampatsa, Gareth O. Griffiths   +39 more
doaj   +1 more source

Pleural Mesothelioma Presenting as Periumbilical Metastasis: The First Clinical Documentation

Case Reports in Oncological Medicine, 2013
Introduction. Pleural mesothelioma with metastasis to the subcutaneous tissue of the abdominal wall at first diagnosis and without penetration into the peritoneum is an extremely rare clinical presentation. Methods.
R. F. Falkenstern-Ge, M. Kimmich, S. Bode-Erdmann, G. Friedel, G. Ott, M. Kohlhäufl   +5 more
doaj   +1 more source