Results 121 to 130 of about 1,613,624 (375)
Advanced Science, EarlyView.Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li +14 more
wiley +1 more source
Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Advanced Science, EarlyView.Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang +16 more
wiley +1 more source
Boolean Models of Bistable Biological Systems
, 2009 This paper presents an algorithm for approximating certain types of dynamical systems given by a system of ordinary delay differential equations by a Boolean network model.
A. Novick +16 more
core +1 more source
Corticotropinoma as a Component of Carney Complex. [PDF]
, 2017 Known germline gene abnormalities cause one-fifth of the pituitary adenomas in children and adolescents, but, in contrast with other pituitary tumor types, the genetic causes of corticotropinomas are largely unknown.
Chittiboina, Prashant +11 more
core +2 more sources
Advanced Science, EarlyView.Mobile messenger RNAs (mRNAs) can travel long distances, serving as systemic signals that participate in plant growth and stress acclimation. This work determines that PHR proteins mediate the Pi starvation response (PSR)‐specific long‐distance transport of mRNAs and that these PSR‐specific mobile mRNAs represent noncoding transcripts in recipient ...
Weiguo Dong +9 more
wiley +1 more source
Effect of silencing on proliferation and apoptosis of melanoma cells: An in vivo and in vitro study
Tumor Biology, 2017 This study aimed to investigate the effect of SOCS1 silencing on the proliferation and apoptosis of melanoma cells by in vivo and in vitro studies. Immunohistochemical staining was used to detect SOCS1 expression in melanoma tissues and pigmented nevi ...
Sheng-Jia Yu, Zi-Wen Long
doaj +1 more source
Species-agnostic polymeric formulations for inhalable messenger RNA delivery to the lung
Nature Materials, 2022 L. Rotolo +26 more
semanticscholar +1 more source
Mechanical Cues Regulate Cargo Sorting and Export at the Golgi
Advanced Science, EarlyView.A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino +21 more
wiley +1 more source
The Incidence of Graves’ Hyperthyroidism Before and After COVID-19 Messenger RNA Vaccination [PDF]
, 2023 Mayumi Endo +5 more
openalex +1 more source
Discrimination of messenger RNA [PDF]
FEBS Letters, 1978 Herrlich, Peter, Schweiger, Manfred
openaire +2 more sources