Results 121 to 130 of about 257,181 (321)
Advanced Science, EarlyView.The impact of topography on the secretome of adipose‐derived stem cells (ADSCs) has the potential for promoting tendon regeneration. The secretome generated from ADSCs on aligned structure has a potent effect in promoting cell migration, proliferation, tenogenic differentiation, macrophage M2 polarization, and tendon mechanical function recovery ...
Qiuzi Long +14 more
wiley +1 more source
Advanced Science, EarlyView.LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao +7 more
wiley +1 more source
Advanced Science, EarlyView.Macrophage phenotypes are influenced by the microenvironment. Matrix stiffness, a key ECM factor, polarizes macrophage toward a pro‐regenerative phenotype in a 3D physiological environment. CaMKK2 selectively regulates stiffness‐induced macrophage polarization, impacting tumor growth and wound healing.
Ya Guan +7 more
wiley +1 more source
Advanced Science, EarlyView.The gut microbiome is a potential target for treating cardiovascular disease. It is found that prophylactic administration of Flavonifractor plautii or its metabolite desaminotyrosine (DAT) exerts pleiotropic cardioprotective effects via promoting cardiomyocyte survival and attenuating cardiac inflammation against myocardial ischemia/reperfusion (I/R ...
Heng Du +21 more
wiley +1 more source
Advanced Science, EarlyView.A unique hydrogel based on extracellular matrix from fish swim bladder, which is suitable for transcatheter delivery and possesses remarkable reparative capabilities for treating heart failure, is developed. It emerges as a multi‐effect factor profoundly influencing inflammation regulation, angiogenesis, and myocardial metabolism.
Yulong Fu +9 more
wiley +1 more source
ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2402-2427, December 2022., 2022 Abstract Nucleic acids are the blueprint of life. They are not only the construction plan of the single cell or higher associations of them, but also necessary for function, communication and regulation. Due to the pandemic, the attention shifted in particular to their therapeutic potential as a vaccine. As pharmaceutical oligonucleotides are unique in
Robert Minkner +3 more
wiley +1 more source
Oligonucleotide mapping of non-radioactive virus and messenger RNAs [PDF]
, 1977 David Frisby
openalex +1 more source
Advanced Science, EarlyView.This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo +10 more
wiley +1 more source