Results 181 to 190 of about 1,613,624 (375)

Cancer Manipulates Adjacent Adipose Tissue to Exploit Fatty Acids via HIF‐1α/CCL2/PPARα Axis: A Metabolic Circuit to Support Tumor Progression

Advanced Science, EarlyView.
Cancer cells drive adjacent adipose tissue to release fatty acids by secreting CCL2, which activates PPARα‐dependent lipolysis. The resulting fatty acid influx amplifies HIF‐1α/CCL2 signaling, establishing a positive feedback loop that fuels tumor growth.
Jeong‐Eun Yun, Jieun Seo, Jiwon Koh, Seock‐Ah Im, Ki Yong Hong, Yeseon Son, Do‐Won Jeong, Junji Fukuda, Jong‐Wan Park, Yang‐Sook Chun   +9 more
wiley   +1 more source

Supplementary Notes from Genomic Profiling of MicroRNA and Messenger RNA Reveals Deregulated MicroRNA Expression in Prostate Cancer [PDF]

, 2023
Stefan Ambs, Robyn L. Prueitt, Ming Yi, Robert Hudson, Tiffany M. Howe, Fabio Petrocca, Tiffany A. Wallace, Chang-Gong Liu, Stefano Volinia, George A. Calin, Harris G. Yfantis, Robert M. Stephens, Carlo M. Croce   +12 more
openalex   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

PXR Pharmacogenetics: Association of Haplotypes with Hepatic CYP3A4 and ABCB1 Messenger RNA Expression and Doxorubicin Clearance in Asian Breast Cancer Patients

, 2008
Edwin Sandanaraj, Suman Lal, Viknesvaran Selvarajan, London Lucien Ooi, Zee Wan Wong, Nan Soon Wong, Peter Ang, Edmund J.D. Lee, Balram Chowbay   +8 more
openalex   +2 more sources

Changes in hepatic messenger RNA for phospho enol pyruvate carboxykinase (GTP) during development [PDF]

, 1978
Josefa P. Garcia Ruiz, Robert S. Ingram, Richard W. Hanson   +2 more
openalex   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system.

, 1986
Scott R. Whittemore, Ted Ebendal, Lena Lärkfors, Linus Olson, Å. Seiger, Ingrid Strömberg, Håkan Persson   +6 more
openalex   +2 more sources

Cellular Localization of Ovarian Proopiomelanocortin Messenger RNA during Follicular and Luteal Development in the Rat [PDF]

, 1990
Sheryl L. Sanders, Michael H. Melner, Thomas E. Curry   +2 more
openalex   +1 more source

Humoral Immune Response to Messenger RNA COVID-19 Vaccines Among Patients With Inflammatory Bowel Disease [PDF]

, 2021
Michael D. Kappelman, Kimberly N. Weaver, Margie Boccieri, Ann M. Firestine, Xian Zhang, Millie D. Long, Kelly Chun, M. Fernando, Michael Zikry, Xiangfeng Dai, Runa Watkins, Jeremy Adler, Marla C. Dubinsky, Arthur Kastl, Athos Bousvaros, Jennifer Strople, Raymond K. Cross, Peter Higgins, Ryan C. Ungaro, Meenakshi Bewtra, Emanuelle Bellaguarda, Francis A. Farraye   +21 more
openalex   +1 more source

NOX2‐Driven Oxidative Stress Promotes EndMT and Uncouples Angiogenesis–Osteogenesis at the Bone–Implant Interface in Diabetes

Advanced Science, EarlyView.
NOX2‐driven oxidative stress disrupts angiogenesis–osteogenesis coupling at the diabetic bone–implant interface. Pharmacologic inhibition and endothelial‐specific NOX2 knockout restore type‐H endothelium, suppress EndMT, and improve osseointegration.
Zimei Wu, Qiaodan Hou, Yang Liu, Tingting Chen, Kunkun Yang, Luyao Li, Lin Wang   +6 more
wiley   +1 more source