Results 191 to 200 of about 312,118 (258)

The je ne sais quoi of 5-methylcytosine in messenger RNA. [PDF]

RNA
Guarnacci M, Preiss T.
europepmc   +1 more source

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure

Clinical Pharmacology &Therapeutics, EarlyView.
This study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Anssi J. H. Mykkänen, Päivi Hirvensalo, Kathrin Klein, Dorota Kaminska, Markus Grube, Tuija Tapaninen, Johanna I. Kiiski, Mikko Neuvonen, Ville T. Männistö, Jussi Pihlajamäki, Mladen Tzvetkov, Matthias Schwab, Aleksi Tornio, Janne T. Backman, Mikko Niemi   +14 more
wiley   +1 more source

Identification of plasma exosomal microRNAs and bioinformatics analysis of the microRNA-messenger RNA regulatory pathways in mice with status epilepticus. [PDF]

Cytotechnology
Wang W, Yin J, Yin J.
europepmc   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Messenger RNA Therapy for Female Reproductive Health. [PDF]

Mol Pharm
VanKeulen-Miller R, Fenton OS.
europepmc   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

[The function of circular RNA-microRNA-messenger RNA immune regulatory network in childhood allergic asthma]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Huang SH, Zhou JT, Wang Y, Han X.
europepmc   +1 more source

Integrity assay for messenger RNA in mouse and human brain samples and synaptosomal preparations. [PDF]

iScience
Bujanauskiene D, Merkevicius K, Kuliesiute U, Denkovskij J, Kutanovas S, Luksys G, Rocka S, Bernotiene E, Neniskyte U.   +8 more
europepmc   +1 more source

A Phase 1/2 Randomized Study to Evaluate the Safety, Tolerability, and Immunogenicity of Nucleoside-Modified Messenger RNA Influenza Vaccines in Healthy Adults. [PDF]

Vaccines (Basel)
Branche A, Mulligan MJ, Maniar A, Puente O, Oladipupo I, Crowther G, Zareba AM, Yi Z, Scully I, Gomme E, Koury K, Kitchin N, Allen PS, Anderson AS, Gurtman A, Lindert K.   +15 more
europepmc   +1 more source

MicroRNA target homeobox messenger RNA in HIV induced hematopoietic inhibition. [PDF]

Front Cell Dev Biol
Koka PS, Ramdass B.
europepmc   +1 more source