From Viral Vaccines to Messenger RNA Vaccines
Pakistan Journal of Medicine and Dentistry, 2020 Today, the swiftness of epidemics of infectious disease is alarming. To date vaccines have been an enormous success for not only preventing but completely eradicating a number of malicious infectious disease like small pox, rubella, mumps, measles and ...
Saeeda Baig, Zoha Asghar
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m6A-dependent regulation of messenger RNA stability
Nature, 2013 N6-methyladenosine (m6A) is the most prevalent internal (non-cap) modification present in the messenger RNA of all higher eukaryotes. Although essential to cell viability and development, the exact role of m6A modification remains to be determined.
Xiao Wang +12 more
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Technology in Cancer Research & Treatment, 2020 This study was designed to identify novel circular RNAs and the related regulatory axis to provide research targets for the diagnosis and treatment of breast cancer.
Ziqi Peng BM, Boyang Xu BM, Feng Jin MD
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Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. [PDF]
, 2013 The 3' untranslated region (3'UTR) of hepatitis C virus (HCV) messenger RNA stimulates viral translation by an undetermined mechanism. We identified a high affinity interaction, conserved among different HCV genotypes, between the HCV 3'UTR and the host ...
Bai, Yun +2 more
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The roles of the subunits in the function of the calcium channel [PDF]
, 1991 Dihydropyridine-sensitive voltage-dependent L-type calcium channels are critical to excitation-secretion and excitation-contraction coupling. The channel molecule is a complex of the main, pore-forming subunit alpha 1 and four additional subunits: alpha ...
Biel, Martin +5 more
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Theoretical basis for stabilizing messenger RNA through secondary structure design
bioRxiv, 2020 RNA hydrolysis presents problems in manufacturing, long-term storage, world-wide delivery, and in vivo stability of messenger RNA (mRNA)-based vaccines and therapeutics.
H. Wayment-Steele +10 more
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Cotranslational microRNA mediated messenger RNA destabilization
eLife, 2016 MicroRNAs are small (22 nucleotide) regulatory molecules that play important roles in a wide variety of biological processes. These RNAs, which bind to targeted mRNAs via limited base pairing interactions, act to reduce protein production from those ...
Trinh To Tat +4 more
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Ultrastructure of the ribonucleoprotein and messenger-like ribonucleic acid of the polyribosomes isolated from Rous sarcoma virus-induced mouse ascites sarcoma cells [PDF]
, 1974 Electron microscopic observation was made on the length distibution of messenger RNA molecules in polyribosome pre· paration isolated from mouse ascites sarcoma cells, which was de· stroyed by ethylenediamine tetraacetate treatment in hypotonic solu ...
Oda, Takuzo, Yamamoto, Goki
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Vaccines against Coronavirus Type 19: An Overview [PDF]
Al-Anbar Medical Journal, 2023 Vaccines are biological agents that provide immunity against certain diseases [1]. Vaccination is an effective technique for prevention of infection and control outbreak of a wide range of infectious diseases (https://apps.who.int/iris/handle/10665 ...
Makwan Abdulkareem
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HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs [PDF]
, 2019 HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA recognition motifs (RRMs) where the structure and RNA binding of RRM3 and of ...
Asami S +4 more
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