Results 31 to 40 of about 488,806 (353)
HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs [PDF]
, 2019 HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA recognition motifs (RRMs) where the structure and RNA binding of RRM3 and of ...
Asami S +4 more
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RNA interference as a novel treatment strategy for chronic hepatitis B infection [PDF]
Clinical and Molecular Hepatology, 2022 Chronic hepatitis B (CHB) is a major cause of liver-related morbidity and mortality. Functional cure of CHB, defined as sustainable hepatitis B surface antigen (HBsAg) seroclearance, is associated with improved clinical outcomes. However, functional cure
Rex Wan-Hin Hui +3 more
doaj +1 more source
Biochemical Aspects of Genetics [PDF]
, 1965 It would be impossible, in the time and space available, to cover all of the noteworthy advances that have been made in biochemical genetics during the past year.
Horowitz, N. H., Metzenberg, Robert L.
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Processivity and coupling in messenger RNA transcription.
PLoS ONE, 2010 BackgroundThe complexity of messenger RNA processing is now being uncovered by experimental techniques that are capable of detecting individual copies of mRNA in cells, and by quantitative real-time observations that reveal the kinetics.
Stuart Aitken +5 more
doaj +1 more source
Frontiers in Genetics, 2023 Genetic and epigenetic reprogramming caused by disease states in other tissues is always systemically reflected in peripheral blood leukocytes (PBLs).
Yinli He +10 more
doaj +1 more source
Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch [PDF]
, 2006 Riboswitches are highly structured elements in the 50-untranslated regions (50-UTRs) of messenger RNA that control gene expression by specifically binding to small metabolite molecules. They consist of an aptamer domain responsible for ligand binding and
Noeske, Jonas +5 more
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The emerging role of RNA modifications in the regulation of mRNA stability
Experimental and Molecular Medicine, 2020 Gene activity: the significance of RNA modification Messenger RNA molecules play their key role in directing the manufacture of proteins via translating the genetic information in DNA.
Sung Ho Boo, Yoon Ki Kim
doaj +1 more source
A thermostable messenger RNA based vaccine against rabies. [PDF]
PLoS Neglected Tropical Diseases, 2017 Although effective rabies virus vaccines have been existing for decades, each year, rabies virus infections still cause around 50.000 fatalities worldwide. Most of these cases occur in developing countries, where these vaccines are not available.
Lothar Stitz +8 more
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Modelling ribosome kinetics and translational control on dynamic mRNA.
PLoS Computational Biology, 2023 The control of protein synthesis and the overall levels of various proteins in the cell is critical for achieving homoeostasis. Regulation of protein levels can occur at the transcriptional level, where the total number of messenger RNAs in the overall ...
Eric C Dykeman
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Messenger RNA Fluctuations and Regulatory RNAs Shape the Dynamics of Negative Feedback Loop
, 2010 Single cell experiments of simple regulatory networks can markedly differ from cell population experiments. Such differences arise from stochastic events in individual cells that are averaged out in cell populations.
Furman, Itay +4 more
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