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, 2021 Messenger RNA medicines are basically sets of instructions and these instructions direct cells in the body to make proteins. mRNA plays a key role in human biology and it is a molecule that carries genetic code from DNA in a cell nucleus to ribosomes the protein making machinery of cells. Messenger RNA carries the genetic information copied from DNA in
openaire +2 more sources
Eukaryotic translation initiation factors and cancer
Tumor Biology, 2017 Recent technological advancements have shown tremendous mechanistic accomplishments in our understanding of the mechanism of messenger RNA translation in eukaryotic cells.
Muhammad Umar Ali +3 more
doaj +1 more source
Advances in Materials, 2019 A main challenge to broaden the biomedical application of CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat (CRISPR) associated protein 9) genome editing technique is the delivery of Cas9 nuclease and single‐guide RNA (sgRNA) into the
Ji Liu +7 more
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The importance of circulating tumor products as „liquid biopsies” in colorectal cancer [PDF]
, 2018 Liquid biopsies represent an array of plasma analysis tests that are studied to evaluate and identify circulating tumor products, especially circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA).
Calborean, Veronica +6 more
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Frontiers in Genetics, 2023 Genetic and epigenetic reprogramming caused by disease states in other tissues is always systemically reflected in peripheral blood leukocytes (PBLs).
Yinli He +10 more
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The messenger: the structure of RNA [PDF]
Biochemical Journal, 2006 In the early part of the 20th Century, the nature of nucleic acid and what its role was within the cell were a bit of a mystery. DNA itself was first isolated as far back as 1869 by the Swiss chemist Johann Friedrich Miescher. He separated nuclei from the cytoplasm of cells and then isolated an acidic substance from these nuclei that he called nuclein1.
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BRUCE: a program for the detection of transfer-messenger RNA genes in nucleotide sequences [PDF]
, 2002 A computer program, BRUCE, was developed for the identification of transfer‐messenger RNA (tmRNA) genes. The program employs heuristic algorithms to search for a tRNAAla‐like secondary structure surrounding a short sequence encoding the tag peptide.
Andersson, S., Canback, B., Laslett, D.
core +3 more sources
Processivity and coupling in messenger RNA transcription.
PLoS ONE, 2010 BackgroundThe complexity of messenger RNA processing is now being uncovered by experimental techniques that are capable of detecting individual copies of mRNA in cells, and by quantitative real-time observations that reveal the kinetics.
Stuart Aitken +5 more
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Nanoscale platforms for messenger RNA delivery.
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2019 Messenger RNA (mRNA) has become a promising class of drugs for diverse therapeutic applications in the past few years. A series of clinical trials are ongoing or will be initiated in the near future for the treatment of a variety of diseases.
Bin Li, Xinfu Zhang, Yizhou Dong
semanticscholar +1 more source
Interacting RNA polymerase motors on DNA track: effects of traffic congestion and intrinsic noise on RNA synthesis [PDF]
Physical Review E 77, 011921 (2008), 2007 RNA polymerase (RNAP) is an enzyme that synthesizes a messenger RNA (mRNA) strand which is complementary to a single-stranded DNA template. From the perspective of physicists, an RNAP is a molecular motor that utilizes chemical energy input to move along the track formed by a DNA. In many circumstances, which are described in this paper, a large number
arxiv +1 more source