Results 91 to 100 of about 433,729 (235)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Erlotinib e metástases cerebrais

Revista Portuguesa de Pneumologia, 2008
Resumo: Relatamos dois casos de carcinoma pulmonar de não pequenas células (CPNPC) com metástases cerebrais que após quimioterapia sistémica receberam em segunda e terceira linha erlotinib 150 mg/dia, oral, com resposta completa das lesões secundárias ...
Fernando Barata, Teresa Costa, Ana Figueiredo   +2 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Perfusão isolada de membro com hipertermia na trataento das metástases em trânsito do melanoma cutâneo

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Avaliar a casuística do Setor de Tumores Cutâneos da Disciplina de Cirurgia Plástica da Escola Paulista de Medicina/ Universidade Federal de São Paulo em relação à Perfusão Isolada de Membro (PIM) para o tratamento das metástases em trânsito do
Victor Pavan Pasin, Andrea Fernandes de Oliveira, Ivan Dunshee de Abranches Oliveira Santos, Lydia Masako Ferreira   +3 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

IMUNOMARCAÇÃO DE CD24 EM TUMORES MAMÁRIOS DE CADELAS E SUAS METÁSTASES

, 2017
Os tumores mamários são as neoplasias mais comuns em cadelas, apresentado três vezes mais tumores quando comparado à mulher. Estudos estimam-se que tumores malignos apresentam incidência que varia entre 68,4% e 73,4%.
Calazans, Sabryna Gouveia, Oliveira, Flávia C., Oliveira, Italo C., Tavares e Azevedo, Iggor Kallyl, Cintra, Priscila Pavini, Magalhães, Georgia Mode, Lima, Gabriela Piovan, Santilli, Juliana, Magalhães, Larissa Fernandes   +8 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Integração entre cirurgia e quimioterapia no tratamento das metástases hepáticas do câncer colorretal

Introdução: O câncer colorretal apresenta elevada incidência e importante potencial metastático, sendo o fígado um dos principais locais de disseminação da doença. As metástases hepáticas estão associadas a pior prognóstico, porém os avanços nas técnicas
Bernardo Rosito Azevedo, Murilo Godoy Klein, Marcelo dos Santos Cales, Vinícius Ribeiro Travassos, Eduardo Santos, Gustavo Vendramini Foss, Pedro Junior Goedert De Freitas, Maria Fernanda Lemos Rocha, Juliana Nobre Kelbouscas, Erik Pizzato Machry   +9 more
core   +1 more source

Observação de um caso de adenomatose com metástases renais, em caprino

, 2014
A case of pulmonary adenomatosis in a goat imported from England is studied. Metastases to the kidney were observed. Histologically the tumor consisted of columnar cells which lined the alveoli.
Novloski, G.
core   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source