Results 101 to 110 of about 426,694 (229)

Metastatic primary lung tumor in three dogs
Tumor primário pulmonar metastático em três cães

Semina: Ciências Agrárias, 2012
Primary lung tumors (PLT) are uncommon in dogs and occasionally metastasize to distant organs. This report describes three cases of PLT in dogs with epithelial origin, diagnosed post mortem through histopathology and immunohistochemistry.
Antônio Carlos Faria dos Reis, Ana Paula Frederico Rodrigues Loureiro Bracarense, Danilo Gouveia Wasques, Kerriel Thandile Green, Elisângela Olegário da Silva   +4 more
doaj  

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A Complexidade das Metástases Cardíacas: Desafios Diagnósticos e Terapêuticos em Oncologia Moderna [PDF]

As metástases cardíacas, apesar de raras, representam uma complicação crítica em pacientes com câncer avançado, frequentemente associadas a neoplasias de pulmão, mama e melanoma.
do Nascimento, Maria Júlia Dacas Dacheux, Companhoni, Maria Gabriela, Hummig, Daniel, Spigolon, Lara Novakowski, Machado, Jolmar Leonardo Penazzo, Omairi, Mohamad Jihad, da Cunha, Jessé Alves, Dazzi, Aline Reinert, Thomé, Juliana Tadeu, Sauer, Vitor Roque, Bernardi, Tuany Caroline, Fernandes, Natally Gabrielly Martin, Campiol, Giulia Wichoski   +12 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Metástases Vertebrais: Breve Revisão do Estado da Arte

Gazeta Médica, 2017
O tratamento das metástases vertebrais sofreu uma evolução relevante nos últimos anos, com o desenvolvimento tecnológico da radioterapia/radiocirurgia estereotáxica, novas combinações de quimioterapia e imunoterapia, assentes numa nova subclassificação ...
Bruno Santiago, João Levy Melancia, Manuel Cunha e Sá   +2 more
doaj   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Hepatectomia laparoscópica no tratamento das metástases hepáticas

, 2017
Descreve-se experiência inicial e resultados imediatos da hepatectomia laparoscópica no tratamento de metástases hepáticas em quatro pacientes. Uma paciente foi submetida a hepatectomia direita e três foram submetidas a bissegmentectomia 6-7.
Machado, Marcel Autran C., Machado, Marcel C. C., Makdissi, Fabio F., Almeida, Felipe A. Rocha de, Martins, Antonio Cavalcanti de A., Luiz-Neto, Manoel   +5 more
core  

Hepatectomia para metástases hepáticas de câncer de mama

Revista do Colégio Brasileiro de Cirurgiões
Patients with metastatic breast cancer, whereas liver is the only site of dissemination, may benefit from hepatectomy. Literature suggests that surgical treatment of these metastases may offer a longer survival rate than systemic chemotherapy and/or ...
Antonio Nocchi Kalil, Camila Severa
doaj   +1 more source