Results 111 to 120 of about 426,694 (229)
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
, 2017 We studied 58 patients with distant metastases of differentiated thyroid carcinoma diagnosed after initial therapy. Lymph node metastases were observed in 65% of the patients on initial presentation.
Rezende, Leonardo Lamego +5 more
core
Metástases de adenocarcinoma de vesícula biliar em colecistectomia videolaparoscópica
Revista do Colégio Brasileiro de CirurgiõesThe cancer of the gallbladder unless rare, has been found in about 1% of all cholecistectomies for chronic cholecistitis. The preoperative diagnosis is difficult to be done because there are not particular symptoms.
Antônio Ziliotto Júnior +4 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Metástases hepáticas como apresentação inicial de neoplasia oculta
A dor abdominal em idosos, especialmente quando inespecífica e sem sinais de alarme, pode ocultar diagnósticos graves. Metástases hepáticas frequentemente são a apresentação inicial de tumores sólidos, mas podem passar despercebidas em quadros clínicos ...
Takahasi, Bianca Namie Abe +2 more
core +1 more source
Metástases pulmonares no câncer de mama: revisão dos achados nos exames diagnósticos por imagem
O câncer de mama é a doença maligna mais comum nas mulheres em todo o mundo. Durante os últimos anos, foram feitos muitos avanços no diagnóstico precoce e no tratamento o que conduziu a uma maior taxa de sobrevivência.
Ribeiro, Isadora Pimenta
core +1 more source
Avaliação da eficácia da radiocirurgia estereotáxica no tratamento de metástases cerebrais: análise retrospectiva de resultados clínicos [PDF]
Introdução: As metástases cerebrais representam uma complicação frequente em pacientes com câncer, influenciando substancialmente a morbi-mortalidade e a qualidade de vida.
Rodrigues, Lucas Messias Caze +8 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source