Results 111 to 120 of about 433,729 (235)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Metástases intestinais de melanoma

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: O melanoma maligno é a causa mais comum de doença metastática envolvendo o trato gastrointestinal, e o intestino delgado o sítio mais freqüentemente envolvido.
Flávio Daniel Saavedra Tomasich, Viviane Coimbra Augusto Demarchi, Murilo de Almeida Luz, Luiz Antonio Negrão Dias, Massakazu Kato   +4 more
doaj   +1 more source

Evolução da terapêutica cirúrgica das metástases pulmonares

, 2023
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2023As metástases pulmonares são tumores malignos secundários que se vão localizar no parênquima pulmonar, afetando cerca de 30% dos doentes com ...
Ferreira, Ana Raquel dos Reis
core  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Tumor de células gigantes de fémur distal com metástases pulmonares Giant cell tumour of distal femur with pulmonary metastases

Revista Portuguesa de Pneumologia, 2010
O tumor de células gigantes é uma lesão óssea primária benigna que acomete a epífise de ossos longos, com maior incidência na terceira e quarta décadas de vida, mas que pode apresentar comportamento de um tumor maligno, com metástases à distância.
Nicolas S Lazaretti, Viviane Weiller Dallagasperina, Rodrigo Ughini Villaroel, Luis Alberto Schlittler   +3 more
doaj  

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Estudo da correlação entre o estadiamento clínico e as alterações esqueléticas das metástases ósseas do câncer da mama Correlation between clinical staging and skeletal alterations of bone metastases in breast cancer patients

, 2001
Foram estudadas 48 pacientes com câncer da mama e que apresentavam metástases ósseas, com o objetivo de avaliar-se a correlação entre o estadiamento clínico do tumor primário, de acordo com protocolo do Comitê Americano de Estadiamento do Câncer, e as ...
Helton L.A. Defino, Sérgio Bighetti, Leonardo C. Simionato, Flávio L. Garcia, Ângelo C.S. Matthes   +4 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Imunomarcação da transição epitélio-mesenquima na neoplasia mamária primária de cadelas e sua metástaseem linfonodo

Pesquisa Veterinária Brasileira
RESUMO: Os carcinomas mamários em cães apresentam alta capacidade metastática o que confere menor sobrevida para os pacientes com este tipo de neoplasia.
Larissa Fernandes Magalhães, Geórgia Modé Magalhães, Sabryna Gouveia Calazans, Leandro Zuccolloto Crivellenti, Gabriela Piovan Lima, Alessandra Aparecida Medeiros-Ronchi   +5 more
doaj   +1 more source