Results 131 to 140 of about 413,432 (237)

Ecografia com contraste intravenoso na avaliação de metástases hepáticas de carcinoma colo-rectal: estudo comparativo com tomografia computorizada multidetectores

, 2009
O Carcinoma colo-rectal é a patologia maligna gastrointestinal mais comum e a segunda causa de morte mais comum por neoplasia. Num quarto dos novos casos diagnosticados com carcinoma colo-rectal primário existe metastização hepática e em quase metade ...
Henriques, Daniel André Martins
core  

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Adebrelimab-based regimens as first-line treatment for ES-SCLC in specific populations: a real-world study in Chinese patients. [PDF]

Ther Adv Med Oncol
Jiang L, Wen J, Xu S, Meng L, Zhai N, Shao Z, Wu P, Zhao K, Kong L, Peng J, Huang Z, Meng X.   +11 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Carcinoma neuroendócrino de pâncreas com metástases hepáticas e adrenais: relato de caso

Os tumores neuroendócrinos de pâncreas (TNEP) são neoplasias raras, representando menos de 5% das neoplasias pancreáticas. Apresentam comportamento clínico variável, podendo ser indolentes ou agressivos, e frequentemente são diagnosticados em estágios ...
Magnabosco, Felipe Ferraz, Montenegro, Fábio Luiz de Menezes, Barbosa, José Frederico Rabelo, Brescia, Marília D’Elboux Guimarães   +3 more
core   +1 more source

Targeting B7-H3 in patients with metastatic triple-negative breast cancer and brain metastases: an opportunity to "revive" immunotherapy as a treatment strategy? [PDF]

J Immunother Cancer
Kojundzic I, Zatzman C, Belone Lopes J, Ramay R, Bayani J, Spears M, Jerzak KJ.   +6 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Carcinoma adrenocortical funcional com metástases pulmonares em paciente jovem: relato de caso

 O carcinoma adrenocortical (CAC) é uma neoplasia rara e agressiva que pode causar produção excessiva de hormônios esteróides, especialmente cortisol, resultando em síndrome de Cushing.
Severino, Vitória Fernandes, Campêlo, José Vinicius da Silva, Consonni, Francesco Scodiero, Martines, Brenda, Frati, Rodrigo, Cunha, Marco Antonio Araujo   +5 more
core   +1 more source