Results 121 to 130 of about 433,729 (235)

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Mortality is higher in patients with leptomeningeal metastasis in spinal cord tumors Mortalidade é mais elevada na disseminação metastática leptomeníngea em tumores da medula espinhal

Arquivos de Neuro-Psiquiatria, 2013
Spinal cord tumors are a rare neoplasm of the central nervous system (CNS). The occurrence of metastases is related to poor prognosis. The authors analyzed one series of metastasis cases and their associated mortality.
Ricardo de Amoreira Gepp, José Mauro Cardoso Couto, Maria Dorvalina da Silva, Marco Rolando Sainz Quiroga   +3 more
doaj  

Manifestacoes clínicas e diagnóstico de metástases distantes de carcinoma diferenciado de tireóide após a terapia inicial

, 2017
We studied 58 patients with distant metastases of differentiated thyroid carcinoma diagnosed after initial therapy. Lymph node metastases were observed in 65% of the patients on initial presentation.
Rezende, Leonardo Lamego, Padrao, Eduardo L., Cardoso, Ludmilla David, Barroso, Alvaro Luis, Rosario, Pedro Weslley S. do, Purisch, Saulo   +5 more
core  

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Carcinoma neuroendócrino de pâncreas com metástases hepáticas e adrenais: relato de caso

Os tumores neuroendócrinos de pâncreas (TNEP) são neoplasias raras, representando menos de 5% das neoplasias pancreáticas. Apresentam comportamento clínico variável, podendo ser indolentes ou agressivos, e frequentemente são diagnosticados em estágios ...
Magnabosco, Felipe Ferraz, Montenegro, Fábio Luiz de Menezes, Barbosa, José Frederico Rabelo, Brescia, Marília D’Elboux Guimarães   +3 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

A IMPORTÂNCIA DO DIAGNÓSTICO PRECOCE DEMETÁSTASES CUTÂNEAS DE NEOPLASIAS INTERNAS

UNINGÁ Review, 2013
A pele pode apresentar importantes sinais que revelam aexistência de neoplasias internas.Por meio de lesões cutâ-neas, podem-se detectar tumores em estágios iniciais, o quealtera o prognóstico da doença e o seu tratamento.As me-tástases cutâneas ...
Altemar Boeira de Araujo, Anderson Batista Barbosa, Cleudir Bellé Júnior, Disóstenes da Silva Almeida, Priscila Wolf Nassif   +4 more
doaj  

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Adenocarcinoma de corpo e cauda do pâncreas com metástases hepáticas em paciente idosa: relato de caso

O câncer de pâncreas é uma neoplasia agressiva, frequentemente diagnosticada em estágios avançados devido à apresentação inicial inespecífica, como dor abdominal, náuseas, inapetência e perda de peso.
Menezes, Lucas de Gouveia Pestana Travassos de, Canedo, Paulo José Pouparina, Waridel, Débora, Martines, Brenda, Rocha, Edson Gabriel, Frati, Rodrigo   +5 more
core   +1 more source