Results 151 to 160 of about 412,114 (244)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Surgical management of spinal metastases from primary lung carcinoma: demographics, clinical characteristics, and outcomes-A retrospective analysis. [PDF]

Front Surg
Li J, Zheng Y, Lv X, Zeng R, Zhao Y, Xiang Y, Zhan K, Liu C, Long H, Chen K.   +9 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Múltiplas Metástases Intracardíacas – Um Coração Rosário [PDF]

Arquivos Brasileiros de Cardiologia
Mariana Tinoco, Margarida Castro, Hans Dabó, Filipa Cordeiro, Pedro von Hafe, António Lourenço   +5 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Cancro Ginecológico – consensos nacionais 2013 [PDF]

, 2016
Afonso, Noémia, Agostinho, Paulo Gil, Aldinhas, Paulo, Alves, Boaventura, Andrade, Maria João, Barros, Carlos, Barros, Margarida, Bartosch, Carla, Belo, Joana, Bernardino, Margarida, Boto, Isabel, Branco, Elisabete Castelo, Broco, Sofia, Carvalho, Luísa, Carvalho, Teresa, Castro, Pedro Vieira de, Coelho, Clara, Correia, Paulo, Cortes, Paulo, Costa, Ana Marta, Couto, Rosário, Cruz, Eugénia, Cruz, Mónica, Cunha, Teresa Margarida, Fernandes, Daniel, Ferreira, Marta, Frutuoso, Cristina, Félix, Ana, Gaspar, Hugo, Henriques, Isabel, Jorge, Ana Francisca, Lagoa, António, Lapa, Paula, Lourenço, Rosa, Madeira, Pedro, Martins, Francisco Nogueira, Martins, Nuno Nogueira, Melo, Gilberto, Mota, Fernando, Moutinho, José, Nabais, Henrique, Nave, Mónica, Nogueira, Madalena, Noruegas, Maria José, Patrício, Vanda, Pazos, Isabel, Peralta, Fátima, Pereira, Deolinda, Pereira, José Silva, Petiz, Almerinda, Pontes, Manuel, Pregal, Alexandra, Rebelo, Teresa, Ribas, Paulo, Rocha, Mara, Rodrigues, Henrique, Salgado, Lurdes, Santana, Isabel, Santos, Filomena, Silva, Teresa Simões, Soares, Orlando, Soares, Paula, Sofia, Alexandra Rico, Sousa, Rita, Sá, Joana Bordalo e, Sá, Luís, Vieira, Guy   +66 more
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Region-Based Segmentation of Lymph Node Metastases in Whole-Slide Images of Colorectal Cancer: A Pilot Clinical Study. [PDF]

Cancer Med
Fayzullin A, Savelov N, Balkivskiy A, Ivanova E, Timakova A, Funtikov V, Shelomentseva E, Panchenko N, Spiridonov I, Korkonishko I, Makhina M, Kutuzova E, Meretukov D, Kretova N, Demura T, Timashev P, Parchiev R.   +16 more
europepmc   +1 more source

Carcinoma da cavidade oral: revisão bibliográfica e apresentação de um caso clínico. [PDF]

, 2012
Ana Isabel Henriques Montezinho
core  

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source