Results 91 to 100 of about 88,730 (192)
Oligodendroglioma anaplásico metastático
Galicia Clínica, 2018 Metastization from a brain primary tumor is a rare event. The mechanisms of metastization and the best treatment approach are still unknown. Knowledge is, so far, mostly based on case reports.
Ana Sofia Patrão +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Glioblastoma como metástasis de cáncer hepático
, 2009 Imagen de un glioblastoma surgido como metástasis de un cáncer hepático.Picture of a glioblastoma created as a result of the metastasis of a liver ...
Iglesias Rozas, José Rafael, 1942-
core
Metástasis cutánea de tumor urotelial vesical
, 2003 Queremos presentar un caso de carcinoma vesical de células transicionales, donde el primer signo de progresión de la enfermedad fue la aparición de una metástasis cutánea.
Pascual Regueiro,D. +6 more
core +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Metástasis ósea de cáncer bronquial
, 2009 Dos imágenes de una metástasis ósea de un cáncer bronquial en un paciente de 58 años.Two pictures of a bone metastasis of a bronchial cancer in a 58-year-old male ...
Iglesias Rozas, José Rafael, 1942-
core
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Metástasis ovárica de carcinoma de células renales primario [PDF]
, 2008 Objetivo: Presentar un caso de metástasis ovárica secundaria a un carcinoma de células claras renal. Método/Resultados: Mujer de 52 años que consultó por metrorragias siendo inicialmente diagnosticada de carcinoma primario de ovario.
Álvarez Múgica,Miguel +7 more
core +1 more source