Results 61 to 70 of about 805,322 (205)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Metástasis de carcinoma epidermoide a la glándula mamaria

Revista Colombiana de Cirugía, 2003
Se presenta el caso de una paciente de 63 aíios de edad con antecedente de quemadura en miemhro superior derecho durante la primera infancia, sin otros datos de importancia. Presenta un tumor ulcero vegetante localizado en la cicatriz de la quemadura
Jairo De la Peña Vargas, Hernando Miranda, Angel Heredia, Ernesto Sánchez, Virgilia Soto, Luis Díaz, Pomponio Luján, Lesbia Rivera   +7 more
doaj  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Detección de cáncer oculto de mama metastásico con compromiso ocular. Presentación de un caso clínico

QhaliKay, 2018
El cáncer de mama es la neoplasia más frecuente en el sexo femenino y la segunda causa de muerte por cáncer en la mujer, puede hacer metástasis en pulmón, hígado, hueso, cerebro y órbita, representando esta última menos del 1 % de los casos reportados ...
Dadier Marrero González, Lizeet López Díaz, María Isabel Aldama Rodríguez   +2 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Caracterización clínica epidemiológica de pacientes operados de tumores raquimedulares

Revista Cubana de Medicina Militar, 2019
Introducción: Los tumores raquimedulares son la mayor causa de morbilidad y mortalidad entre pacientes con afecciones oncológicas y representan aproximadamente del 10 al 15 % de todos los tumores del sistema nervioso central.
Alpha Singuepire, Héctor Figueredo Acosta, Kirenia Fonseca Sosa   +2 more
doaj  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Biomarcadores para determinar factores de riesgo y complicaciones postquirúrgicas en pacientes con gastrectomía. Revisión de literatura

Ciencia & Salud
En la actualidad se cuenta con diversos enfoques y medidas terapéuticas para un paciente con cáncer gástrico. La gastrectomía es uno de los procedimientos quirúrgicos más utilizado en la práctica clínica para su tratamiento.
Luis Miguel Flórez Castaño
doaj   +1 more source

Oligodendroglioma anaplásico metastático

Galicia Clínica, 2018
Metastization from a brain primary tumor is a rare event. The mechanisms of metastization and the best treatment approach are still unknown. Knowledge is, so far, mostly based on case reports.
Ana Sofia Patrão, Inês Sequeira, Manuel Jacóme, Joaquina Maurício   +3 more
doaj   +1 more source