Results 61 to 70 of about 843,307 (205)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Metástasis de carcinoma epidermoide a la glándula mamaria

Revista Colombiana de Cirugía, 2003
Se presenta el caso de una paciente de 63 aíios de edad con antecedente de quemadura en miemhro superior derecho durante la primera infancia, sin otros datos de importancia. Presenta un tumor ulcero vegetante localizado en la cicatriz de la quemadura
Jairo De la Peña Vargas, Hernando Miranda, Angel Heredia, Ernesto Sánchez, Virgilia Soto, Luis Díaz, Pomponio Luján, Lesbia Rivera   +7 more
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Caracterización clínica epidemiológica de pacientes operados de tumores raquimedulares

Revista Cubana de Medicina Militar, 2019
Introducción: Los tumores raquimedulares son la mayor causa de morbilidad y mortalidad entre pacientes con afecciones oncológicas y representan aproximadamente del 10 al 15 % de todos los tumores del sistema nervioso central.
Alpha Singuepire, Héctor Figueredo Acosta, Kirenia Fonseca Sosa   +2 more
doaj  

Detección de cáncer oculto de mama metastásico con compromiso ocular. Presentación de un caso clínico

QhaliKay, 2018
El cáncer de mama es la neoplasia más frecuente en el sexo femenino y la segunda causa de muerte por cáncer en la mujer, puede hacer metástasis en pulmón, hígado, hueso, cerebro y órbita, representando esta última menos del 1 % de los casos reportados ...
Dadier Marrero González, Lizeet López Díaz, María Isabel Aldama Rodríguez   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Biomarcadores para determinar factores de riesgo y complicaciones postquirúrgicas en pacientes con gastrectomía. Revisión de literatura

Ciencia & Salud
En la actualidad se cuenta con diversos enfoques y medidas terapéuticas para un paciente con cáncer gástrico. La gastrectomía es uno de los procedimientos quirúrgicos más utilizado en la práctica clínica para su tratamiento.
Luis Miguel Flórez Castaño
doaj   +1 more source

Oligodendroglioma anaplásico metastático

Galicia Clínica, 2018
Metastization from a brain primary tumor is a rare event. The mechanisms of metastization and the best treatment approach are still unknown. Knowledge is, so far, mostly based on case reports.
Ana Sofia Patrão, Inês Sequeira, Manuel Jacóme, Joaquina Maurício   +3 more
doaj   +1 more source