Results 111 to 120 of about 226,196 (309)

Accelerated learning techniques for the foreign language classroom

open access: yesPer Linguam : A Journal of Language Learning, 2013
Recently researchers and teachers have noticed that more and more students have trouble learning. The causes for poor student learning are many and varied.
W. Jane Bancroft
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Institutions and organizations

open access: yes, 2014
Markets are not the only place where transactions take place. ‘Institutions and organizations’ highlights other platforms and institutions — families, social groups and networks, industry associations, and governments — where some transactions work ...
Avinash Dixit
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Ni Schulfranz. ni LCO… Quelle didactique pour les langues familiales quand elles sont « langues étrangères » ?

open access: yesBabylonia, 2023
Le projet « Politiques linguistiques familiales et institutions scolaires : les cas de parents francophones à Berne » met en lumière l’engagement des parents dans la transmission des langues familiales en ville germanophone de Bern mais révèle aussi ...
Jésabel Robin
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Met pensioen en toch aan het werk - het werkgeversperspectief: de rol van leeftijdsbewust personeelsbeleid [PDF]

open access: yes, 2014
Een steeds groter deel van de Nederlandse bevolking blijft actief op de arbeidsmarkt na (vervroegde) pensionering. Veel oudere werknemers blijken een voorkeur te hebben voor geleidelijke uittreding uit het arbeidsproces.
Henkens, C.J.I.M.   +2 more
core  

Institutions for Collective Action: Kroniek van een Bazenbondje, interview met Cees ten Have

open access: yes, 2018
Cees ten Have is ruim 16 jaar secretaris van het Bazenbondje. Hij is zijdelings familie van de familie De Ruyter, waaronder een aantal penningmeesters van het Bazenbondje en eigenaren van café 't Sluisje, het vergaderlokaal van het Bazenbondje, te vinden
Jager, MA E. J. de (Stichting Reis van de Razzia), ProjectLeader
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

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