Results 81 to 90 of about 226,196 (309)
Journal of The Korean Association For Science Education, 2012 Abstract: With an emphasis on scientific literary, science education has again became closer to the interests and needs of people and sometimes expands its scope beyond the boundaries of school and the curriculum. Science educators often claim that its historical roots can be traced back to the movements of General Science and Science and Citizenship ...
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PLOS ONE, 2015 Neoadjuvant chemo-radiotherapy (CRT) followed by surgical resection is the standard treatment for locally advanced rectal cancer, although complete tumor pathological regression is achieved in only up to 30% of cases. A clinicopathological and molecular predictive stratification of patients with advanced rectal cancer is still lacking.
Rebecca Senetta +15 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Are Dutch Water Safety Institutions Prepared for Climate Change?
, 2010 This paper deals with the question to what extent the historically grown Dutch water safety institutions have the capacity to cope with the ‘new’ challenges of climate change. The Adaptive Capacity Wheel provides the methodological framework.
Brink, M.H., van den +2 more
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The Pause on Avian H5N1 Influenza Virus Transmission Research Should Be Ended
mBio, 2012 A voluntary 60-day pause on avian H5N1 influenza virus transmission research was announced in January 2012 by the international community of influenza scientists engaged in this work to provide time to explain the benefits of such work and the risk ...
Ron A. M. Fouchier +2 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
How Dutch Institutions Enhance the Adaptive Capacity of Society
, 2010 This report examines the adaptive capacity of the institutional framework of the Netherlands to cope with the impacts of climate change. Historically, institutions have evolved incrementally to deal with existing social problems.
Termeer, C. +18 more
core
, 2023 South Carolina laws require that each state agency publish and submit to the Governor and the General Assembly an annual accountability report that contains the agency's or department's mission, objectives to accomplish the mission, and performance ...
South Carolina Board of Financial Institutions
core
De la difficile naissance d’un État-nation d’après I Pugnalatori de Leonardo Sciascia
Italies, 2002 Palerme 1862-1863 : des actes terroristes assombrissent la naissance de l’État italien. Des poignardeurs commettent des attentats contre des passants ordinaires.
Marie-Anne Rubat du Mérac
doaj +1 more source
Procedia - Social and Behavioral Sciences, 2014 AbstractGlobalization has made intercultural communication inevitable. Communicating with other cultures characterizes today's workplace, classroom, and community. Intercultural communication is of importance in any career field, but for maritime institutions, especially, this topic has become a ‚must-have’ of education.The teacher faces new challenges
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