Results 1 to 10 of about 3,290,125 (315)

Possible mechanism of metabolic and drug resistance with L-asparaginase therapy in childhood leukaemia

Frontiers in Oncology, 2023
L-asparaginase, which hydrolyzes asparagine into aspartic acid and ammonia, is frequently used to treat acute lymphoblastic leukaemia in children. When combined with other chemotherapy drugs, the event-free survival rate is 90%. Due to immunogenicity and
Ruizhi Zhou, Tianqi Liang, Tianwen Li, Junbin Huang, Chun Chen   +4 more
doaj   +1 more source

Prevention and Treatment of Cardiometabolic Diseases in Children with Overweight and Obesity: The Future of Healthcare

Children, 2022
In this Special Issue we will consider the impact of obesity on health in order to review the latest findings on the risk factors associated with cardiometabolic diseases in children with overweight and obesity as well as to explore the pathogenic ...
Valeria Calcaterra, Gianvincenzo Zuccotti   +1 more
doaj   +1 more source

Metabolite Profiling and Comparative Metabolomics Analysis of Jiaozhou Chinese Cabbage (Brassica rapa L. ssp. pekinensis) Planted in Different Areas

Frontiers in Bioscience-Landmark, 2023
Background: Chinese cabbage (Brassica rapa L. ssp. pekinensis) is one of the most popular vegetables in China because of its taste and health benefits. The area of production has obvious effects on the quality of Chinese cabbage.
Jingjuan Li, Minghui Qiu, Faujiah Nurhasanah Ritonga, Fengde Wang, Dandan Zhou, Cheng Li, Huayin Li, Yihui Zhang, Jianwei Gao   +8 more
doaj   +1 more source

Effects of Temperature and Salinity on Growth, Metabolism and Digestive Enzymes Synthesis of Goniopora columna

Biology, 2022
Climate change is causing dramatic changes in global ocean temperature and salinity, threatening coral survival. Coral growth and metabolism are greatly affected by the temperature, salinity and feeding time of the environment.
De-Sing Ding, Anil Kumar Patel, Reeta Rani Singhania, Chiu-Wen Chen, Cheng-Di Dong   +4 more
doaj   +1 more source

Tissue-Specific and Differential Cold Responses in the Domesticated Cold Tolerant Fugu

Fishes, 2022
Domestication can be defined as the artificial selection in animals to achieve morphological, physiological, and developmental conformity to human needs, with the aim of improving various limitations in species under a human feeding environment.
Shuang Han, Shang Wei, Ruoyu Chen, Man Ni, Liangbiao Chen   +4 more
doaj   +1 more source

Identification of the Carbohydrate and Organic Acid Metabolism Genes Responsible for Brix in Tomato Fruit by Transcriptome and Metabolome Analysis

Frontiers in Genetics, 2021
BackgroundSugar and organic acids not only contribute to the formation of soluble solids (Brix) but also are an essential factor affecting the overall flavor intensity.
Ning Li, Ning Li, Juan Wang, Baike Wang, Shaoyong Huang, Shaoyong Huang, Jiahui Hu, Tao Yang, Patiguli Asmutola, Haiyan Lan, Yu Qinghui   +10 more
doaj   +1 more source

Sex Differences in Cumulative Exposure to Metabolic Risk Factors Before Hypertension Onset: The Cohort of the Tehran Lipid and Glucose Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Previous studies have shown a sex difference in the association between hypertension and cardiovascular disease; however, the precise mechanism remains unclear.
Azra Ramezankhani, Fereidoun Azizi, Amir Abbas Momenan, Farzad Hadaegh   +3 more
doaj   +1 more source

Computational analyses of RPIA gene mutation causing Ribose-5-phosphate isomerase deficiency: a rarest known metabolic disorder in humans

Journal of Taibah University for Science, 2023
The main aim of current study was to perform in silico functional analysis of all reported RPIA mutations. In silico analysis was done using different tools i.e. trRosetta tool, Autodock Vina, PatchDock and iMODS. Among all the reported mutations, lowest
Muhammad Muzammal, Sana Fatima, Aisha Gul, Junaid Qayum, Arshad Farid, Safeer Ahmad, Wasim Shah, Muzammil Ahmad Khan   +7 more
doaj   +1 more source

Neurodegeneration with Brain Iron Accumulation: Diagnosis and Management [PDF]

Journal of Movement Disorders, 2015
Neurodegeneration with brain iron accumulation (NBIA) encompasses a group of inherited disorders that share the clinical features of an extrapyramidal movement disorder accompanied by varying degrees of intellectual disability and abnormal iron ...
Penelope Hogarth
doaj   +1 more source

Endothelial Function and Postprandial Glucose Control in Response to Test-Meals Containing Herbs and Spices in Adults With Overweight/Obesity

Frontiers in Nutrition, 2022
ObjectivesHerbs and Spices (H/S) contain bioactive compounds with purported health benefits. This study investigated the effect of H/S intake on indicators of vascular and metabolic health over 24 h using a test-meal challenge paradigm in adults with ...
Yudai Huang, Meng-Fu Tsai, Rajrajeshwari Sunil Thorat, Di Xiao, Xuhuiqun Zhang, Amandeep K. Sandhu, Indika Edirisinghe, Britt M. Burton-Freeman   +7 more
doaj   +1 more source