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Essays in Biochemistry, 2020 Abstract Metabolism consists of a series of reactions that occur within cells of living organisms to sustain life. The process of metabolism involves many interconnected cellular pathways to ultimately provide cells with the energy required to carry out their function.
Ayesha Judge, Michael S. Dodd
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Glucocorticoids, metabolism and metabolic diseases [PDF]
Molecular and Cellular Endocrinology, 2007 Since the discovery of the beneficial effects of adrenocortical extracts for treating adrenal insufficiency more than 80 years ago, glucocorticoids (GC) and their cognate, intracellular receptor, the glucocorticoid receptor (GR) have been characterized as critical components of the delicate hormonal control system that determines energy homeostasis in ...
Vegiopoulos, Alexandros, Herzig, Stephan
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NAD+ Metabolism, Metabolic Stress, and Infection [PDF]
Frontiers in Molecular Biosciences, 2021 Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite with wide-ranging and significant roles in the cell. Defects in NAD+ metabolism have been associated with many human disorders; it is therefore an emerging therapeutic target. Moreover, NAD+ metabolism is perturbed during colonization by a variety of pathogens, either due to the ...
Groth, Benjamin +2 more
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Fructose Metabolism and Cardiac Metabolic Stress [PDF]
Frontiers in Pharmacology, 2021 Cardiovascular disease is one of the leading causes of mortality in diabetes. High fructose consumption has been linked with the development of diabetes and cardiovascular disease. Serum and cardiac tissue fructose levels are elevated in diabetic patients, and cardiac production of fructose via the intracellular polyol pathway is upregulated.
M. Annandale +11 more
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A statistical mechanics description of environmental variability in metabolic networks [PDF]
, 2014 Many of the chemical reactions that take place within a living cell are irreversible. Due to evolutionary pressures, the number of allowable reactions within these systems are highly constrained and thus the resulting metabolic networks display ...
Crofts, J.J. +3 more
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MicroRNAs in Metabolism and Metabolic Diseases [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2011 Aberrant cholesterol/lipid homeostasis is linked to a number of diseases prevalent in the developed world, including metabolic syndrome, type II diabetes, and cardiovascular disease. We have previously uncovered gene regulatory mechanisms of the sterol regulatory element-binding protein (SREBP) family of transcription factors, which control the ...
V, Rottiers +10 more
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Frontiers in Neurology, 2022 ObjectiveAcupuncture has been shown to be effective in the treatment of chronic pain. However, their neural mechanism underlying the effective acupuncture response to chronic pain is still unclear.
Jin Xu +9 more
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Prevalence of Metabolic Syndrome in Psychiatric Inpatients: A Naturalistic Study [PDF]
, 2010 The aim of this naturalistic survey was to measure the prevalence of metabolic syndrome by collating data on routine physical investigation in an acute psychiatric inpatient population.
Batugedara, Anuja +4 more
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Fructose metabolism and metabolic disease [PDF]
Journal of Clinical Investigation, 2018 Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of sugar may be particularly harmful.
Herman, Mark A +3 more
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MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]
, 2012 Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
Kierzek, A.M. +37 more
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