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Topiramate and Metabolic Acidosis

Epilepsia, 1999
Summary: Topiramate (TPM) is a novel antiepileptic medication (AED) with at least three mechanisms of action. A possible fourth mechanism, that of a carbonic anhydrase inhibitor, also may contribute to its antiepileptic properties. We report a patient with intractable epilepsy and normal renal function who developed a normal anion gap metabolic ...
A, Wilner, K, Raymond, R, Pollard
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Treatment of metabolic acidosis

Current Opinion in Critical Care, 2003
Metabolic acidosis is characterized by a decrease of the blood pH associated with a decrease in the bicarbonate concentration. This may be secondary to a decrease in the strong ion difference or to an increase in the weak acids concentration, mainly the inorganic phosphorus. From a conceptual point of view, two types of nontoxic metabolic acidosis must
Jacques, Levraut, Dominique, Grimaud
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Hyperchloraemic metabolic acidosis

Emergency Medicine Journal, 2008
Cholestyramine carries a risk of hyperchloraemic metabolic acidosis. Being cognisant of this drug-induced adverse event may reduce diagnostic delays. Emergency physicians should be alert about this condition, in particular among patients with pre-existing chronic kidney disease, or who are taking spironolactone.
F S Y, Fan   +3 more
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Metabolic Acidosis

Respiratory Care, 2001
Metabolic acidosis occurs in a number of diseases and even certain normal activities such as heavy exercise. It arises from increased endogenous acid production, exogenous acid (or acid-precursor) administration, base losses, and depression of renal acid secretion.
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PHENFORMIN AND METABOLIC ACIDOSIS

The Lancet, 1972
Abstract A patient with oliguric renal failure complicating accelerated hypertension was given phenformin and ethylœstrenol as fibrinolytic therapy. On the fifth day of this treatment a profound and fatal metabolic acidosis developed despite good control of uraemia by peritoneal dialysis. The acidosis was resistant to 2500 meq.
G A, MacGregor   +2 more
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Phenformin-associated metabolic acidosis

Diabetes, 1976
We report 18 consecutive phenformin-treated diabetic patients admitted to this Medical Service acutely ill with metabolic acidosis. Lactic acidosis was anticipated, and documented, in all. Also, however, though most of the patients had only weakly positive, or even negative, serum reactions with the nitroprusside reagent, all were found to have ...
M, Fulop, H D, Hoberman
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Cardiovascular responses to metabolic acidosis

American Journal of Physiology-Legacy Content, 1965
The performance of the left ventricle was examined in a feline preparation which allowed precise control of aortic pressure, cardiac output, heart rate, and temperature. The arterial pH, Po2, and Pco2 were continuously measured with a Jewett flow-through electrode assembly.
S E, DOWNING, N S, TALNER, T H, GARDNER
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Metabolic Acidosis—Diabetic

Archives of Internal Medicine, 1965
METABOLIC ACIDOSIS is a clinical state characterized by an excess of hydrogen ions, the source of which are acids other than carbonic. In diabetic acidosis, the source of the excessive hydrogen ion is ketoacids formed during the process of intermediary metabolism in the absence of insulin. The degree of acidemia, ie, lowering of arterial blood pH, will
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[Metabolic acidosis].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2016
Metabolic acidosis is frequently observed in clinical practice, especially among critically ill patients and/or in the course of renal failure. Complex mechanisms are involved, in most cases identifiable by medical history, pathophysiology-based diagnostic reasoning and measure of some key acid-base parameters that are easily available or calculable ...
Regolisti G.   +9 more
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