Results 151 to 160 of about 360,017 (261)

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

The metabolic burden associated with plasmid acquisition: An assessment of the unrecognized benefits to host cells. [PDF]

Bioessays
Curtsinger HD, Martínez-Absalón S, Liu Y, Lopatkin AJ.   +3 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Residual metabolic burden in young psoriasis patients successfully treated with biologics. [PDF]

Arch Dermatol Res
Merzel Šabović EK, Kraner Šumenjak T, Janić M.   +2 more
europepmc   +1 more source

CRISPR-based curing and analysis of metabolic burden of cryptic plasmids in Escherichia coli Nissle 1917. [PDF]

Eng Life Sci, 2019
Zainuddin HS, Bai Y, Mansell TJ.
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Proteomics and metabolic burden analysis to understand the impact of recombinant protein production in E. coli. [PDF]

Sci Rep
Rajacharya GH, Sharma A, Yazdani SS.
europepmc   +1 more source

Nonalcoholic fatty liver disease represents a greater metabolic burden in patients with atherosclerosis: A cross-sectional study. [PDF]

Medicine (Baltimore), 2019
Han J, Wang Y, Yuan Z, Liu L, Zhao M, Guan Q, Zhang H, Li Q, Xu J, Gao L, Zhao J, Zhang X.   +11 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Nonalcoholic fatty liver disease incidence and impact on metabolic burden and death: A 20 year-community study. [PDF]

Hepatology, 2018
Allen AM, Therneau TM, Larson JJ, Coward A, Somers VK, Kamath PS.   +5 more
europepmc   +1 more source