Results 121 to 130 of about 1,944 (252)

Autophagy maintains the metabolism and function of young and old stem cells

, 2017
With age, haematopoietic stem cells lose their ability to regenerate the blood system, and promote disease development. Autophagy is associated with health and longevity, and is critical for protecting haematopoietic stem cells from metabolic stress ...
Warr, Matthew R, Theodore T. Ho, Ho, Theodore T, Figueroa, Maria E, Verovskaya, Evgenia V, Evgenia V. Verovskaya, Emmanuelle Passegué, Flach, Johanna, Maria E. Figueroa, Matthew R. Warr, Johanna Flach, Lansinger, Olivia M, Emmalee R. Adelman, Olivia M. Lansinger, Passegué, Emmanuelle, Adelman, Emmalee R   +15 more
core   +1 more source

Pathobiochemistry of Aging and Neurodegeneration: Deregulation of NAD+ Metabolism in Brain Cells

Biomolecules
NAD+ plays a pivotal role in energy metabolism and adaptation to external stimuli and stressful conditions. A significant reduction in intracellular NAD+ levels is associated with aging and contributes to the development of chronic cardiovascular, neurodegenerative, and metabolic diseases.
Nataliya A. Kolotyeva, Alexander A. Groshkov, Nataliya A. Rozanova, Arseniy K. Berdnikov, Svetlana V. Novikova, Yulia K. Komleva, Alla B. Salmina, Sergey N. Illarioshkin, Mikhail A. Piradov   +8 more
openaire   +3 more sources

GOVERNING THE CLOUD: Infrastructural Statecraft and the Political Ecology of Digital Expansion in Oregon

International Journal of Urban and Regional Research, EarlyView.
Abstract Oregon's wave of data center and semiconductor projects shows how cloud capitalism reorganizes resource systems and territorial governance. Examining Amazon, Google, and Intel, the article traces how fiscal incentives, utility programs, and land‐use instruments are recalibrated to secure hyperscale loads.
Justin Kollar
wiley   +1 more source

Testicular SIRT1 Loss Reveals an Aging‐Like Proteomic Landscape and Precipitates Reproductive Deterioration

Andrology, EarlyView.
ABSTRACT Background Advanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD+‐dependent deacetylase, plays a pivotal role in maintaining oxidative balance and cellular homeostasis.
María Iniesta‐Cuerda, Jiřina Havránková, Hedvika Řimnáčová, Jiří Moravec, František Liška, Martin Knytl, Milena Králíčková, Jan Nevoral   +7 more
wiley   +1 more source

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

Brain Pathology, EarlyView.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira, Yaiza López‐Sampere, Pol Mengod‐Soler, Mario Peña‐Fonteboa, Carla Marco, Alejandro Caravaca‐Puchades, Raúl Domínguez, Juan Francisco Vázquez‐Costa, Enrique Santamaría, Joaquín Fernández‐Irigoyen, María J. Colomina, Isabel León Moreno, Antonio Martínez Yélamos, Sergio Martínez Yélamos, Gabriel Santpere, Elia Obis, Manuel Portero‐Otín, Gerard Piñol‐Ripoll, Mónica Povedano, Pol Andrés‐Benito   +19 more
wiley   +1 more source

Metabolic Checkpoints in Cancer Cell Cycle

, 2014
Growth factors (GFs) as well as nutrient sufficiency regulate cell division in metazoans. The vast majority of mutations that contribute to cancer are in genes that regulate progression through the G1 phase of the cell cycle.
Saqcena, Mahesh
core  

Relationship Between PTBP1 and Pancreatic Cancer Based on microRNA and Behavior During TYMS‐Mediated Carcinogenesis

Cancer Science, EarlyView.
Corresponding Author and colleagues identify a pancreas‐enriched microRNA, miR‐216b‐5p, that suppresses PTBP1 and its downstream effector TYMS. Their findings reveal a novel miR‐216b‐5p/PTBP1/TYMS regulatory axis driving pancreatic cancer progression and establish PTBP1 as a central molecular regulator of tumor biology beyond its metabolic role ...
Shigenori Suzuki, Hiroaki Hase, Yosuke Inomata, Jun Arima, Kentaro Jingushi, Atsushi Tomioka, Nao Kawaguchi, Hiroki Hamamoto, Ryo Tanaka, Yoshiro Imai, Mitsuhiro Asakuma, Tomohito Tanaka, Kazutake Tsujikawa, Kohei Taniguchi, Sang‐Woong Lee   +14 more
wiley   +1 more source

Extranodal Marginal Zone Lymphoma: Integrating Etiology, Microenvironment, and Genetics Into Clinical Decision‐Making

European Journal of Haematology, EarlyView.
ABSTRACT Extranodal marginal zone lymphoma (EMZL) represents a unique paradigm among indolent B‐cell neoplasms, in which lymphomagenesis is frequently driven by chronic antigenic stimulation within tissue‐specific microenvironments. Persistent infectious or autoimmune triggers promote the development of ectopic lymphoid tissue and sustain B‐cell ...
Mamdouh Skafi, Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Marco Fiorillo, Eugenio Lucia, Graziella D'Arrigo, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Giovanni Tripepi, Fortunato Morabito, Massimo Gentile   +15 more
wiley   +1 more source

Metabolic reprogramming in AML : Clinical impact and oncogenic mechanisms

, 2020
Le métabolisme des cellules cancéreuses est fortement perturbé et dérégulé dans les cancers. Plusieurs exemples illustrent ce phénomène, notamment la reprogrammation métabolique décrite dans l’effet Warburg, les dérégulations fonctionnelles de certaines ...
Lo Presti, Caroline
core  

Regulation and deregulation of cholesterol homeostasis: the liver as metabolic “power station”

, 2012
Cholesterol plays several structural and metabolic roles that are vital for human biology. It spreads along the entire plasma membrane of the cell modulating fluidity and concentrating in specialized sphingolipid-rich domains called rafts and caveolae ...
PALLOTTINI, Valentina, Segatto M, Trapani L   +2 more
core   +1 more source