Results 131 to 140 of about 1,774 (249)

Physiology Reimagined: Molecular, Metabolic, and Microenvironmental Forces Driving Epithelial Cancers. [PDF]

Curr Issues Mol Biol
Scheau C, Caruntu A.
europepmc   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Metabolic and epigenetic interplay in HSPC specification: A balance between extrinsic and intrinsic cues. [PDF]

iScience
Kalogeraki M, Rondeau V, Abou Nader Z, Espéli M, Balabanian K.   +4 more
europepmc   +1 more source

NDUFS1‐Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation

MedComm, Volume 7, Issue 4, April 2026.
Pancreatic cancer stem cells (CSCs) maintain stemness and tumorigenicity through NDUFS1‐mediated complex I activity, which is transcriptionally upregulated via the CD147‐STAT3 signaling axis. Enhanced oxidative phosphorylation (OXPHOS) and NAD+ production driven by this CD147‐NDUFS1 axis subsequently trigger the SIRT1‐DNMT1 metaboloepigenetic signaling
Xin‐Yu Fan, Wen Li, Ying Shi, Bao‐Qing Xu, Hao Wang, Ruo‐Fei Tian, Zi‐Chuan Duan, Jing Fan, Jia‐Rong Liu, Xiu‐Xuan Sun, Bin Wang, Li‐Juan Wang, Ke Wang, Shi‐Jie Wang, Xiang‐Min Yang, Hong‐Yong Cui, Zhi‐Nan Chen, Ling Li   +17 more
wiley   +1 more source

Proteome-scale autoantibody profiling in PSC: Associations with clinical phenotypes and evidence for neuroendocrine deregulations. [PDF]

JHEP Rep
Cornillet M, Båve AL, Sun D, Nouairia G, Villard C, Grigoriadis A, von Seth E, Jansson H, Álvez MB, Bergström S, Nilsson P, Uhlén M, Edfors F, Stål P, SweHep consortium, Sparrelid E, Björkström NK, Halfvarson J, Bergquist A.   +18 more
europepmc   +1 more source

Fat Checking: Emerging Role of Lipids in Metabolism and Disease. [PDF]

Int J Mol Sci, 2022
Segatto M, Cutone A, Pallottini V.
europepmc   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Maternal emulsifier consumption alters the offspring early-life microbiota and goblet cell function leading to long-lasting diseases susceptibility. [PDF]

Nat Commun
Delaroque C, Rytter H, Bonazzi E, Huillet M, Ellero-Simatos S, Chatonnat E, Hao F, Patterson A, Chassaing B.   +8 more
europepmc   +1 more source

Childhood OSAS and Obesity: Prospective Associations of Anthropometric Markers With Objective Sleep Outcomes in the CHAT Trial

Journal of Sleep Research, Volume 35, Issue 2, April 2026.
ABSTRACT Obstructive sleep apnea syndrome (OSAS) is characterised by episodic upper airway obstruction that occurs during sleep and is common in children with obesity. The aim of the present study was to analyse the association between baseline anthropometric markers and objective sleep quality measures at follow‐up in school‐aged children with OSAS ...
Catalina Ramírez‐Contreras, Verónica Palma Elgueta, Lautaro Briones‐Suárez   +2 more
wiley   +1 more source

Epigenetic and metabolic rewiring in metastatic pheochromocytomas and paragangliomas driven by SDHB mutations. [PDF]

Commun Biol
Cubiella T, Alba-Linares JJ, San-Juan-Guardado J, Suarez-Priede A, Gómez-Suárez N, Tous M, Bancos I, Villabona C, Serrano T, Tena I, Del Olmo M, Forga L, Valdés N, Fraga MF, Chiara MD.   +14 more
europepmc   +1 more source