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Metabolic Deregulations in Acute Myeloid Leukemia
, 2021 Mossuz P, Chevalier S, Mondet J
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Psychosocial risk factors for the metabolic syndrome: A prospective cohort study
International Journal of Cardiology, 2016 Background/Objectives: Metabolic deregulations and development of metabolic syndrome may be an important pathway underlying the relationship between stress and cardiovascular disease. We aim to estimate the effect of a comprehensive range of psychosocial
Jolene Masters Pedersen +2 more
exaly +2 more sources
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Deregulated transcription factors in cancer cell metabolisms and reprogramming
Seminars in Cancer Biology, 2022Metabolic reprogramming is an important cancer hallmark that plays a key role in cancer malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to generate not only energy and building blocks but also produce numerous key signaling metabolites to impact signaling and epigenetic/transcriptional regulation for cancer cell ...
Rajni, Kant +7 more
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Deregulation of Collagen Metabolism in Human Stomach Cancer
Pathobiology, 2004<i>Objective:</i> The defects of collagen metabolism are responsible for the disorganization of extracellular matrix in stomach cancer. Collagen through interaction with integrin receptors regulates the cellular growth, differentiation, gene expression, prolidase and gelatinase activity and plays an important role in tumorigenesis and ...
Tomasz Guszczyn, Krzysztof Sobolewski
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Deregulated Sphingolipid Metabolism and Membrane Organization in Neurodegenerative Disorders
Molecular Neurobiology, 2010Sphingolipids are polar membrane lipids present as minor components in eukaryotic cell membranes. Sphingolipids are highly enriched in nervous cells, where they exert important biological functions. They deeply affect the structural and geometrical properties and the lateral order of cellular membranes, modulate the function of several membrane ...
M. Piccinini +12 more
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Deregulated Tyrosine–Phenylalanine Metabolism in Pulmonary Tuberculosis Patients
Journal of Proteome Research, 2015Metabolic profiling of biofluids from tuberculosis (TB) patients would help us in understanding the disease pathophysiology and may also be useful for the development of novel diagnostics and host-directed therapy. In this pilot study we have compared the urine metabolic profiles of two groups of subjects having similar TB symptoms and categorized as ...
Mrinal Kumar, Das +7 more
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Purine metabolism gene deregulation in
AimsTo explore alterations in the expression of genes encoding enzymes involved in purine metabolism in Parkinson's disease (PD) brains as purines are the core of the DNA, RNA, nucleosides and nucleotides which participate in a wide variety of crucial metabolic pathways.MethodsAnalysis of mRNA using real‐time quantitative PCR of 22 genes involved in ...
Paula, Garcia-Esparcia +4 more
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Deregulation of carbohydrate metabolism in patients with sleep apnoea
European Respiratory Journal, 2011Material and methods: The study included 103 new patients with the following characteristics: 50±12 years of age, BMI 30.2±5.8 kg/m 2 , neck circumference 42±7 cm, Epworth 11±10, AHI 33±27 h-1, DI 34±28 h-1, mean SpO2 91±9% minimum SpO2 76±14%, CT 90 22±30%.
Juan Fernández-Lahera +8 more
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Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice
Blood, 2005Abstract Evidence is accumulating that hepcidin, a liver regulatory peptide, could be the common pathogenetic denominator of all forms of iron overload syndromes including HFE-related hemochromatosis, the most prevalent genetic disorder characterized by inappropriate iron absorption. To understand the mechanisms whereby hepcidin controls
Lydie, Viatte +7 more
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