Results 121 to 130 of about 12,548,139 (260)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Primary cilia dysfunction: A critical driver of metabolic diseases (Review). [PDF]

Int J Mol Med
Wang X, Jin Y, Xie K, Yao P, Song L, Liu H, Tan Y.   +6 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Quercetin in metabolic diseases: mechanisms, therapeutics, and multidimensional frontiers. [PDF]

Front Endocrinol (Lausanne)
Song Q, Liu L, Yang Q, Pan M, Zhang Y.
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Relationship between physical activity and ankle osteoarthritis: Implications for metabolic diseases. [PDF]

PLoS One
Kim WS, Yang HJ, Choi JH, Han HS, Lee DY, Lee KM.   +5 more
europepmc   +1 more source

The Inherited Metabolic Diseases [PDF]

Archives of Disease in Childhood, 1988
openaire   +3 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Genome sequencing identifies monogenic causes in adults with metabolic diseases. [PDF]

J Endocr Soc
Okur V, Marcus A, Falcone JN, Hurd MA, Stewart SL, Claudio K, Manohar J, Dealla F, Kumar S, Yeung M, Dakin G, Bellorin-Marin O, Afaneh C, Hudgins LC, Wei E, Gingras L, King A, Tung J, Rehman AU, Thomas-Wilson A, Guha S, Abhyankar A, Wilson AL, Khan SY, Srinivasa ST, Phadke S, Krithivasan P, Nava C, Chen S, Smith R, MacDonald TY, Ritter MJ, Alonso LC, Elemento O, Udler MS, Peña JM, Jobanputra V, Goncalves MD.   +37 more
europepmc   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source