Results 141 to 150 of about 1,151,626 (269)

Relationship between physical activity and ankle osteoarthritis: Implications for metabolic diseases. [PDF]

PLoS One
Kim WS, Yang HJ, Choi JH, Han HS, Lee DY, Lee KM.   +5 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Genome sequencing identifies monogenic causes in adults with metabolic diseases. [PDF]

J Endocr Soc
Okur V, Marcus A, Falcone JN, Hurd MA, Stewart SL, Claudio K, Manohar J, Dealla F, Kumar S, Yeung M, Dakin G, Bellorin-Marin O, Afaneh C, Hudgins LC, Wei E, Gingras L, King A, Tung J, Rehman AU, Thomas-Wilson A, Guha S, Abhyankar A, Wilson AL, Khan SY, Srinivasa ST, Phadke S, Krithivasan P, Nava C, Chen S, Smith R, MacDonald TY, Ritter MJ, Alonso LC, Elemento O, Udler MS, Peña JM, Jobanputra V, Goncalves MD.   +37 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

The burden of metabolic diseases in the Arab region, 1990-2021. [PDF]

Ther Adv Endocrinol Metab
Pan Z, Fouad Y, Abaalkhail F, Al Hassani A, Altarrah MY, Derbala M, Abdulla M, Tahiri M, Al-Busafi SA, Alkhalidi N, Hotayt B, Al-Awadhi S, Soliman R, Shiha G, Sanai FM, Eslam M.   +15 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Editorial: Micronutrients and metabolic diseases - volume II. [PDF]

Front Nutr
Li J, Yang A, Luo Y, An P.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Network Toxicology Reveals the Mechanisms of the Plasticizer Metabolite MECPP in Metabolic Diseases. [PDF]

Int J Mol Sci
Qiu J, Cheng C, Jiang B, Yang D, Peng H.
europepmc   +1 more source

The Inherited Metabolic Diseases [PDF]

Archives of Disease in Childhood, 1988
openaire   +3 more sources