Results 181 to 190 of about 1,855,857 (359)

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Nanomedicines Against Mitochondrial Dysfunction-Induced Metabolic Diseases. [PDF]

Adv Sci (Weinh)
Xu K, Wang L, Lv T, Jin C, Wu Q, Zhou Y, Xu G, Duan Z, Luo K, Yang J.   +9 more
europepmc   +1 more source

Metabolism and Disease [PDF]

Proceedings of the Royal Society of Medicine, 1922
openaire   +2 more sources

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Advances in essential oils for metabolic diseases. [PDF]

Front Endocrinol (Lausanne)
Li X, Tong M, Cao H, Sun X, Zhang F.
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

P1–258: Magnetic resonance imaging and Alzheimer's disease: Longitudinal studies of structural and metabolic changes in different transgenic mice models [PDF]

, 2013
Edoardo Micotti, Alessandra Paladini, Daniele Tolomeo, Marta Filibian, Moira Marizzoni, Anna Caroli, Claudia Balducci, Sophie Dix, Laurence Ozmen, Christian Czech, Jill Richardson, Giovanni B. Frisoni, Gianluigi Forloni   +12 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Metabolic diseases and Kupffer cell's plasticity. [PDF]

Immunometabolism (Cobham)
Fantini F, Norata GD.
europepmc   +1 more source

Metabolic Syndrome in Ambulatory People With Post–Polio Syndrome, Charcot-Marie-Tooth Disease, and Other Neuromuscular Diseases

Eric L. Voorn, Sander Oorschot, Nicolette Wierdsma, Maarten R. Soeters, Fieke Sophia Koopman, Annerieke C. van Groenestijn   +5 more
openalex   +1 more source