Results 11 to 20 of about 12,548,139 (260)
MicroRNAs in Metabolism and Metabolic Diseases [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2011 Aberrant cholesterol/lipid homeostasis is linked to a number of diseases prevalent in the developed world, including metabolic syndrome, type II diabetes, and cardiovascular disease. We have previously uncovered gene regulatory mechanisms of the sterol regulatory element-binding protein (SREBP) family of transcription factors, which control the ...
V, Rottiers +10 more
openaire +2 more sources
Fructose metabolism and metabolic disease [PDF]
Journal of Clinical Investigation, 2018 Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of sugar may be particularly harmful.
Herman, Mark A +3 more
openaire +2 more sources
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
Signal Transduction and Targeted Therapy, 2023 The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major public health burden worldwide. The most common form of NCD is metabolic diseases, which affect people of all ages and usually manifest their pathobiology through life ...
Xiumei Wu +6 more
semanticscholar +1 more source
NLRP3 Inflammasome in Cancer and Metabolic Diseases
Nature Immunology, 2021 The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in response to cellular perturbations. This assembly leads to the activation of caspase-1, which promotes maturation and release of the inflammatory cytokines interleukin-1β (
B. Sharma, T. Kanneganti
semanticscholar +1 more source
Novel Role of the SIRT1 in Endocrine and Metabolic Diseases
International Journal on Biological Sciences, 2023 Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent deacetylase, is a cellular regulator that has received extensive attention in recent years and regarded as a sensor of cellular energy and metabolism.
Chenxi Lu +11 more
semanticscholar +1 more source
Metabolism: Clinical and Experimental, 2023 BACKGROUND A significant proportion of premature deaths globally are related to metabolic diseases in young adults. We examined the global trends and mortality of metabolic diseases in individuals aged below 40 years using data from the Global Burden of ...
B. Chong +27 more
semanticscholar +1 more source
Adipose tissue macrophages as potential targets for obesity and metabolic diseases
Frontiers in Immunology, 2023 Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose tissue dysfunction and contributing to obesity-induced inflammation and metabolic disorders.
Xirong Li +6 more
semanticscholar +1 more source
Frontiers in Public Health, 2023 Aging is a progressive and irreversible pathophysiological process that manifests as the decline in tissue and cellular functions, along with a significant increase in the risk of various aging-related diseases, including metabolic diseases.
Kexin Zhang +7 more
semanticscholar +1 more source
New Insights and Potential Therapeutic Interventions in Metabolic Diseases
International Journal of Molecular Sciences, 2023 Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development of new techniques and insights has led to a deeper understanding of the mechanisms underlying these conditions and opened up new ...
V. J. Clemente-Suárez +5 more
semanticscholar +1 more source
Biology of Sex Differences, 2023 Accumulating evidences show that the alterations in the gut microbiota associated to metabolic diseases are different in men and women, and these differences may influence sex differences in the development and prevalence of metabolic diseases.
J. A. Santos-Marcos +4 more
semanticscholar +1 more source