Results 141 to 150 of about 632,889 (322)

Crop metabolic engineering towards enhanced resistance to pests and pathogens

Crop Journal
Plants produce a vast array of specialized metabolites that serve as essential defenses against herbivores and pathogens. However, the capacity to produce these compounds differs substantially among plant species and is frequently diminished during ...
Jiaojiao Wang, Jinyue Yang, Junxing Yu, Yaxian Liu, Youping Wang, Amr El-Demerdash, Wenbin Zhou, Dewei Wu   +7 more
doaj   +1 more source

Regulation-Structured Dynamic Metabolic Model Provides a Potential Mechanism for Delayed Enzyme Response in Denitrification Process [PDF]

, 2017
In a recent study of denitrification dynamics in hyporheic zone sediments, we observed a significant time lag (up to several days) in enzymatic response to the changes in substrate concentration.
Chen, Xingyuan, Fredrickson, Jim K., Li, Minjing, Liu, Chongxuan, Scheibe, Timothy D., Song, Hyun-Seob, Song, Xuehang, Stegen, James C., Thomas, Dennis G., Zachara, John M.   +9 more
core   +1 more source

Plant Metabolic Genetic Engineering [PDF]

openalex   +1 more source

Metabolic engineering of terpene metabolism in lavender

Beni-Suef University Journal of Basic and Applied Sciences
Abstract Background Several members of the Lamiaceae family of plants produce large amounts of essential oil [EO] that find extensive applications in the food, cosmetics, personal hygiene, and alternative medicine industries.
Ojo Michael Oseni, Reza Sajaditabar, Soheil S. Mahmoud   +2 more
openaire   +3 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Advances in Metabolic Engineering of Plant Monoterpene Indole Alkaloids [PDF]

, 2023
Vonny Salim, Sara-Alexis Jarecki, Marshall Vick, Ryan S. Miller   +3 more
openalex   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Metabolic engineering of Bacillus subtilis toward the efficient and stable production of C30-carotenoids [PDF]

, 2023
Oriana Filluelo, Jordi Ferrando, Pere Picart   +2 more
openalex   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source