Results 161 to 170 of about 330,730 (300)

Metabolic Engineering of <i>Rhodotorula toruloides</i> for Biosynthesis of Retinal. [PDF]

J Fungi (Basel)
Qiu H, Tian L, Hu L, Wu L, Huang Y, Ge R, Xing Y, Kamnev AA, He N, Cao M.   +9 more
europepmc   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Systems metabolic engineering for hydroxytyrosol production in <i>Escherichia coli</i>. [PDF]

Appl Environ Microbiol
Jiang W, Chen Z, Fan W, Li C, Li L, Yu Z, Li X, Xu Q.   +7 more
europepmc   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Discovery of feed-forward regulation in L-tryptophan biosynthesis and its use in metabolic engineering of E. coli for efficient tryptophan bioproduction

, 2018
The L-tryptophan (Trp) biosynthesis pathway is highly regulated at multiple levels. The three types of regulations identified so far, namely repression, attenuation, and feedback inhibition have greatly impacted our understanding and engineering of ...
Zeng, An-Ping, Chen, Minliang, Chen, Lin, Ma, Cheng-Wei   +3 more
core  

Metabolic engineering of Bacillus subtilis for high-yield surfactin production. [PDF]

Biotechnol Biofuels Bioprod
Wang Y, Li H, Mao Y, Li P, Wu H, Ye J, Zhang H.   +6 more
europepmc   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Multistep metabolic engineering of Pichia pastoris for biosynthesis of N‑acetylneuraminic acid. [PDF]

Appl Microbiol Biotechnol
Zhao X, Li Q, Luo H, Wang Y, Xu X, Zhang W, Zhang J, Liu B.   +7 more
europepmc   +1 more source

Persistent Bilateral [18F]THK5351 and Migrating Unilateral [18F]FDG Uptake in Anti‐LGI1 Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Anti–leucine‐rich glioma‐inactivated 1 encephalitis (LGI1‐E) can cause persistent cognitive deficits, but the mechanisms remain unclear. A 40‐year‐old woman with LGI1‐E presented with subacute cognitive deficits and showed mild left medial temporal lobe (MTL) swelling and fluid‐attenuated inversion recovery (FLAIR) hyperintensity on initial ...
Yusuke Akitomi, Kenichiro Taira, Masanori Kurihara, Kenji Ishibashi, Kenji Ishii, Fumio Suzuki, Aya Midori Tokumaru, Makoto Hara, Atsushi Iwata   +8 more
wiley   +1 more source

Implications of the Assumptions on Intracellular Metabolic Operational States in Metabolic Control Analysis

Modeling and analysis of metabolic networks is inherently biased by assumptions regarding the intracellular metabolite and flux states. Despite the advanced metabolomics and fluxomics methods at our disposal, the sheer complexity of metabolic networks ...
Hatzimanikatis, Vassily, Fengos, Georgios, Soh, Keng Cher, Chakrabarti, Anirikh, Miskovic, Ljubisa   +4 more
core