Results 171 to 180 of about 330,730 (300)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Metabolic engineering of Streptomyces albulus for de novo serotonin production. [PDF]

Microb Cell Fact
Zhang Y, Liu A, Zhang M, Song J, Wang Q, Liu Y, Yao Q, Kong L, Wang X, Qin J.   +9 more
europepmc   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Quantitative Analysis of Metabolic Networks Through the Explicit Consideration of Kinetic Mechanisms

Engineering of large-scale metabolic pathways to maximize production of a certain substance or to minimize creation of undesired chemicals require explicit information about the underlying enzyme kinetics.
Hatzimanikatis, Vassily, Miskovic, Ljubisa   +1 more
core  

Effect of CO Transfer on Hydrogen Production By Carboxydotrophic Archaeon Thermococcus Onnurineus NA1

, 2014
In recent years biological conversion of syngas or steel mill gas containing carbon monoxide (CO) has been receiving much attention since it offers an exciting opportunity to produce fuels and chemicals from non-food and non-fossil resources.
김태완, 나정걸, 김광호, 정수현, 전상구, 강성균, 정희석   +6 more
core  

Valorization of ligustrum species: biosynthesis, metabolic engineering, and pharmacology of bioactive compounds. [PDF]

Bioresour Bioprocess
Li D, Lu C, Zhang Y, Yu Y, Fei C, Chen P, Fu R, Wu M, Zhou P.   +8 more
europepmc   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Engineering <i>Escherichia coli</i> for Ergothioneine Production via Metabolic Engineering and Fermentation Optimization. [PDF]

Microorganisms
Liu Y, Wen Y, Hu R, Han R, Liu D, Zhang H.   +5 more
europepmc   +1 more source

Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA‐Brasil

Arthritis Care &Research, EarlyView.
Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada, Marcos Rafael N. Cavalcante, Itamar de Souza Santos, Márcio S. Bittencourt, Vandrize Meneghini, Paulo A. Lotufo, Alessandra C. Goulart, Isabela M. Bensenor   +7 more
wiley   +1 more source

Toward a systems metabolic engineering approach to improve thermotolerance of Escherichia coli. [PDF]

Microb Cell Fact
Pérez-Morales G, Merino E, Cevallos MA, Gosset G, Licona-Cassani C, Caspeta L, Martinez A.   +6 more
europepmc   +1 more source