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Developments in metabolic engineering
Current Opinion in Biotechnology, 1997The complete sequencing of several microbial genomes has resulted in the increased availability of genes for metabolic engineering. The number of databases and computational tools to deal with this information has also increased. This development has stimulated, and will continue to stimulate, advances in metabolic engineering. Specific recent advances
Frank W. R. Chaplen, Douglas C. Cameron
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Current Opinion in Biotechnology, 1994
Metabolic engineering is not another form of classic manipulation of intermediary metabolism; rather, it is the purposeful design of metabolic networks. The metabolic engineering approach examines biochemical reactions in their entirety, rather than individually, and is concerned with the construction of novel pathways, the thermodynamic feasibility of
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Metabolic engineering is not another form of classic manipulation of intermediary metabolism; rather, it is the purposeful design of metabolic networks. The metabolic engineering approach examines biochemical reactions in their entirety, rather than individually, and is concerned with the construction of novel pathways, the thermodynamic feasibility of
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2007
Metabolic engineering is a powerful methodology aimed at intelligently designing new biological pathways, systems, and ultimately phenotypes through the use of recombinant DNA technology. Built largely on the theoretical and computational analysis of chemical systems, the field has evolved to incorporate a growing number of genome scale experimental ...
R Michael, Raab +2 more
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Metabolic engineering is a powerful methodology aimed at intelligently designing new biological pathways, systems, and ultimately phenotypes through the use of recombinant DNA technology. Built largely on the theoretical and computational analysis of chemical systems, the field has evolved to incorporate a growing number of genome scale experimental ...
R Michael, Raab +2 more
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Metabolic Fluxes and Metabolic Engineering
Metabolic Engineering, 1999Metabolic engineering is the directed improvement of cellular properties through the modification of specific biochemical reactions or the introduction of new ones, with the use of recombinant DNA technology. As such, metabolic engineering emphasizes metabolic pathway integration and relies on metabolic fluxes as determinants of cell physiology and ...
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Metabolic engineering of Pichia pastoris for malic acid production from methanol
Biotechnology and Bioengineering, 2020The application of rational design in reallocating metabolic flux to accumulate desired chemicals is always restricted by the native regulatory network.
Feng Guo +9 more
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Engineering of Crassulacean Acid Metabolism
Annual Review of Plant Biology, 2021Crassulacean acid metabolism (CAM) has evolved from a C3ground state to increase water use efficiency of photosynthesis. During CAM evolution, selective pressures altered the abundance and expression patterns of C3genes and their regulators to enable the trait. The circadian pattern of CO2fixation and the stomatal opening pattern observed in CAM can be
Schiller, Katharina, Bräutigam, Andrea
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ACS Synthetic Biology, 2020
Metabolic engineering aims to achieve high yields of desired products. The most common strategies focus on optimization of metabolic flux distributions. The dynamic activation or inhibition of gene expression through quorum sensing (QS) has been applied ...
Fei Gu +7 more
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Metabolic engineering aims to achieve high yields of desired products. The most common strategies focus on optimization of metabolic flux distributions. The dynamic activation or inhibition of gene expression through quorum sensing (QS) has been applied ...
Fei Gu +7 more
semanticscholar +1 more source
Engineering the plant metabolic system by exploiting metabolic regulation
The Plant Journal, 2023SUMMARYPlants are the most sophisticated biofactories and sources of food and biofuels present in nature. By engineering plant metabolism, the production of desired compounds can be increased and the nutritional or commercial value of the plant species can be improved.
Selma, Sara +3 more
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2011
Metabolic engineering is the intentional modification of cellular metabolism for the production of desired compounds. With the use of recombinant DNA technology, metabolic pathways of various organisms can be manipulated. Bacteria, fungi, plant, and animal cells are all used as host organisms, and selection is primarily driven by the properties of ...
S. Hou, K.H. Lee, D.M. Wuest
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Metabolic engineering is the intentional modification of cellular metabolism for the production of desired compounds. With the use of recombinant DNA technology, metabolic pathways of various organisms can be manipulated. Bacteria, fungi, plant, and animal cells are all used as host organisms, and selection is primarily driven by the properties of ...
S. Hou, K.H. Lee, D.M. Wuest
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Metabolic flux analysis and metabolic engineering of microorganisms
Mol. BioSyst., 2008Recent advances in metabolic flux analysis including genome-scale constraints-based flux analysis and its applications in metabolic engineering are reviewed. Various computational aspects of constraints-based flux analysis including genome-scale stoichiometric models, additional constraints used for the improved accuracy, and several algorithms for ...
Kim, Hyun Uk +2 more
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