Results 81 to 90 of about 2,044,373 (297)

Distributed Finite-Time State Estimation of Interconnected Complex Metabolic Networks

Complexity, 2018
A set of distributed robust finite-time state observers was developed and tested to estimate the main biochemical substances in interconnected metabolic networks with complex structure.
Alfonso Sepulveda-Galvez, Jesus A. Badillo-Corona, Isaac Chairez   +2 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Differential metabolic responses to hydrogen peroxide-induced oxidative stress in parotid and submandibular gland acinar cell lines

Biochemistry and Biophysics Reports
This study explored how oxidative stress induced by hydrogen peroxide alters metabolite levels in submandibular and parotid salivary gland acinar cells. We investigated the impact of oxidative stress on the metabolite profiles of two salivary gland cell ...
Golnaz Golnarnik, Anni I. Nieminen, Tine M. Søland, Hilde K. Galtung, Trude M. Haug   +4 more
doaj   +1 more source

Metabolic pairing of aerobic and anaerobic production in a one-pot batch cultivation

Biotechnology for Biofuels, 2018
Background The versatility of microbial metabolic pathways enables their utilization in vast number of applications. However, the electron and carbon recovery rates, essentially constrained by limitations of cell energetics, are often too low in terms of
Milla Salmela, Tapio Lehtinen, Elena Efimova, Suvi Santala, Rahul Mangayil   +4 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Hydrogen gas with hypothermic machine perfusion induces lipidomic alterations in donation-after-cardiac-death rat livers

Journal of Lipid Research
Hypothermic machine perfusion (HMP) combined with hydrogen gas has previously been shown to mitigate ischemia-reperfusion injury (IRI) in rat liver, but without full recovery of function.
Yusuke Minami, Siddabasave Gowda B. B. Gowda, Kengo Shibata, Sodai Sakamoto, Divyavani Gowda, Tsuyoshi Shimamura, Akinobu Taketomi, Hitoshi Chiba, Moto Fukai, Shu-Ping Hui   +9 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Voltage-Driven Regulation of Metabolic Flux and Biohydrogen Production in a Dynamic Membrane Bioreactor Coupled with Electro-Fermentation

Hydrogen
Dynamic membrane bioreactors (DMBRs) are promising systems for continuous biohydrogen production because they enable effective biomass retention under short hydraulic retention time (HRT) conditions.
Eunseo Cho, Gi-Beom Kim, Gyucheol Choi, Ju-Hyeong Jung   +3 more
doaj   +1 more source

Artificial intelligence and robotics in the hydrogen lifecycle: A systematic review [PDF]

Data availability statement: No data has been generated in this work.Hydrogen lifecycle, encompassing production, storage, and transportation, is crucial in the global transition to clean energy.
Duan, L, Huda, MN, Quintanilla, P, Lai, CS, Masoudi Soltani, S, Elhalwagy, A, Foroudi, P, Nandy, M   +7 more
core   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source